Antiepileptic Effect of Uncaria rhynchophylla and Rhynchophylline Involved in the Initiation of c-Jun N-Terminal Kinase Phosphorylation of MAPK Signal Pathways in Acute Seizures of Kainic Acid-Treated Rats
Figure 6
Effect of UR and RP on MAPK in KA-induced epileptic seizures in rats. The JNKp expression of MAPK in the cerebral cortex (Cortex) and hippocampus (Hippocampus) brain tissues increased for Groups KA and PK; these increases were lower in Groups UR, RP and VA. The JNK, ERK, ERKp, p38, p38p expression of MAPk in the cerebral cortex and hippocampus brain tissues were similar in Groups N, KA, PK, UR, RP, and VA (p: phosphorylation; N: normal group; KA, KA/control group; PK: PK group; UR: UR group; RP: RP group; VA: VA group). ##P < .01, ###P < .001 compared to PK; ***P < .001 compared to KA.
