Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome
Table 3
Effects of resveratrol and physical exercise on body composition measured by DEXA and bone mineral density measured by pQCT.
Control-vehicle
Control-RSV
PCOS-vehicle
PCOS-RSV
PCOS-exercise
( = 9-10)
()
( = 9-10)
(–)
( = 9-10)
Fat gain (g)
16.3 ± 2.1
13.2 ± 1.3
24.7 ± 3.3*
15.3 ± 2.0#
1.1 ± 2.0###
Fat gain (% of BW)
1.9 ± 0.9
0.9 ± 0.4
2.5 ± 0.8
0.6 ± 0.5
−3.6 ± 0.5###
LBM gain (g)
61.2 ± 6.3
67.2 ± 4.5
86.0 ± 4.0**
79.6 ± 5.5
92.5 ± 7.6
LBM gain (% of BW)
−4.1 ± 0.8
−0.4 ± 2.1
−2.5 ± 0.7
−3.1 ± 1.5
2.6 ± 0.6###
BMC (% of BW)
2.75 ± 0.03
2.74 ± 0.05
2.57 ± 0.3***
2.54 ± 0.03
2.40 ± 0.04##
Tibia length (mm)
35.1 ± 0.3
35.2 ± 0.2
37.2 ± 0.2***
37.1 ± 0.4
36.8 ± 0.2
Total BMD (mg/cm3)
747 ± 14
760 ± 14
638 ± 19***
637 ± 17
643 ± 13
Trabecular BMD (mg/cm3)
480 ± 20
489 ± 23
313 ± 33*
294 ± 27
340 ± 22
Cortical BMD (mg/cm3)
1414 ± 3
1410 ± 5
1405 ± 3
1400 ± 5
1412 ± 3
Delta values before versus after treatment for fat and LBM are presented as mean ± SEM, and BMC and BMD are presented as after treatment values, mean ± SEM. Statistics were calculated using one-way ANOVA with Dunnett’s post hoc test. *, **, *** versus control-vehicle and #, ##, ### versus PCOS-vehicle. BMC: bone mineral content; BMD: bone mineral density; LBM: lean body mass; RSV: resveratrol.
