Resveratrol Is Not as Effective as Physical Exercise for Improving Reproductive and Metabolic Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome
Table 5
Effects of resveratrol and physical exercise on steroidogenesis measured by RT-PCR.
Gene
Control-vehicle
PCOS-vehicle
PCOS-RSV
PCOS-exercise
()
()
()
()
Hsd3b1
1.00 ± 0.10
0.82 ± 0.09
0.84 ± 0.13
1.38 ± 0.14##
CYP17a1
1.00 ± 0.57
5.09 ± 1.57*
4.82 ± 1.38
7.26 ± 2.434
CYP11a1
1.00 ± 0.07
0.49 ± 0.11**
0.61 ± 0.18
0.78 ± 0.13
Responders
PCOS RSV ()
PCOS exercise ()
Hsd3b1
1.11 ± 0.19
1.63 ± 0.14###
CYP17a1
2.71 ± 0.92
7.68 ± 4.31
CYP11a1
1.04 ± 0.21#
1.01 ± 0.12#
Nonresponders
PCOS RSV ()
PCOS exercise ()
Hsd3b1
0.64 ± 0.14
1.11 ± 0.18
CYP17a1
7.01 ± 2.04
7.65 ± 0.92
CYP11a1
0.28 ± 0.17
0.53 ± 0.18
Values are presented as mean ± SEM of ΔΔCT values. Statistics were calculated using the Mann-Whitney test. *P < 0.05, **P < 0.01 versus control-vehicle and #, ##, ### versus PCOS-vehicle. RSV: resveratrol.
