P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells

<table>Schematic of the neuroprotective effects of NGR2 against 6-OHDA-induced neurotoxicity. NGR2 activates P90RSK and Nrf2 via MEK1/2-ERK1/2 pathways. P90RSK activation could inhibit BAD, thereby inhibiting 6-OHDA-induced mitochondrial membrane depolarization, cytochrome c release, caspase-9 and caspase-3 activation, and apoptosis. Nrf2 activation could enhance the activities of phase II detoxifying enzymes such as HO-1, GSH-PX, and GR. This phenomenon suppressed 6-OHDA-induced oxidative stress and DNA fragmentation.</table>

Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells 

Figure 8 | P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells 