| | Group | Change | Term | Genes |
| | NORM-CX | Upregulation | Membrane-enclosed lumen | POLR2F, PNO1, CHCHD4, MRTO4, ATF5, CDCA8, TIMM8A1, C1QBP, MRPL17, SDF2L1, RANGRF, GEMIN6, TFDP1 |
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DEX-CX | Upregulation | Signal peptide | MPZL3, NRP1, MSMB, MMP9, CRHBP, CCL9, ARSJ, GREM1, IL7R, CD68, SMPDL3A, APOE, LTF, EMB, GPNMB, CD27, PRL2C2, SHBG, WNT10A, LPL, LYZ2, CD8B1, ICAM2, TMIE, MDGA2, IL11RA1, STIM1, SIRPA, ACPL2, TMEM66, EMR1, PRL4A1, SLPI, FAIM3 | | Downregulation | Cell cycle | E2F1, CLSPN, CCDC99, PRC1, KNTC1, AURKB, CEP55, CCNE1, NCAPH, MCM7, FANCI, INCENP, CDCA2, CDCA5, CDCA3, KIF11, DLGAP5, SGOL2, LIG1, GMNN, NUSAP1, BIRC5, NDC80, MCM2, ESCO2, ATM, NCAPD2, FANCD2, CCND2, PLK1, SIAH2, CHAF1A, MAD2L2, CHAF1B | | DNA metabolic process | GINS1, KIF22, CLSPN, NUDT1, LIG1, POLE, TREX1, BRIP1, MCM2, MCM10, ESCO2, ATM, CCNE1, MCM7, FANCI, FANCD2, RRM2, RRM1, AICDA, RUVBL2, CHAF1A, TOP2A, CHAF1B | | Cellular response to stress | KIF22, CLSPN, NUDT1, LIG1, POLE, BRIP1, TREX1, ESCO2, ATM, FANCD2, FANCI, IFNG, RUVBL2, EIF2AK2, CHAF1A, CHAF1B | | Nucleotide binding | KIF22, TUBA3B, OAS2, AURKB, GMPPB, WARS, GALK1, PTK2, MCM7, IGTP, NT5C3, OASL2, KIF4, TAP1, OASL1, GBP10, MLKL, MX2, TOP2A, DHX58, GBP6, KIF11, GIMAP7, BC006779, LIG1, POLE, KIF15, IFI47, BRIP1, TREX1, GRHPR, MCM2, ATM, ABCG1, PSMB9, HYOU1, GVIN1, PLK1, PKM2, RRM1, RUVBL2, PGK1, EIF2AK2, OAS1G, GBP3, PAICS, GBP2, GBP1 | | Intracellular nonmembrane-bounded organelle | GYPC, KIF22, CLSPN, ZBTB32, CCDC99, PRC1, HIST1H2AG, TUBA3B, KNTC1, CEP55, AURKB, DAXX, HIST2H2AB, PTK2, FANCI, INCENP, KIF4, ASF1B, TOP2A, DBNL, CENPN, KIF11, MRPS28, NOC4L, DLGAP5, SGOL2, KIF15, TPX2, NUSAP1, BIRC5, NDC80, CSRP1, MCM2, MID1IP1, ATM, CENPI, NCAPD2, APITD1, FANCD2, HIST1H3C | | DNA binding | E2F1, KIF22, CLSPN, HIST1H2AG, TBX21, MYBL2, HIST2H2AB, MCM7, LOC100046232, KIF4, LOC100048299, TOP2A, DHX58, LIG1, POLE, NUSAP1, BRIP1, TREX1, MCM2, STAT1, ESCO2, ATM, STAT2, TRIM30, ATF3, APITD1, JUN, IRF7, IRF8, IRF1, HIST1H3C, RUVBL2 |
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DEX-CP | Upregulation | Cytoplasmic membrane-bounded vesicle | SELP, RAB5B, CAMP, HEXB, RASL2-9, TGFB3, ACTN1, VEZT, CHI3L3, ANXA2, RABAC1, ATP7A, SLC11A1, SYN2, SORT1, LTF, MPO, NEU1, GPNMB, SLC40A1, RIN3, RAB27A | | Signal | NRP1, PLXNA2, FAM20B, CRHBP, MMP9, HEXB, SORL1, ARSJ, PGLYRP1, TGFB3, RETNLG, SIDT1, CD1D1, CD97, TMEM108, LOC100046259, SERPINE2, SLC24A3, APOE, SMPDL3A, LTF, IZUMO1, SEPP1, GPC1, DPP7, RAMP1, NXPH1, RAMP3, WNT10A, CD3G, CD3D, CRTAC1, ICAM2, CAR11, CAMP, TMIE, MDGA2, LRP1B, PTPRR, CST3, IL11RA1, H2-DMB1, SIRPA, HCST, CD84, CCDC3, ACVR2B, H2-OA, PRL4A1, LOC100047936, BACE1, SORT1, FAIM3, ERN2, FCRLA, NEU1, PRNP, CASQ2, CPM, IGFBPL1, MSMB, ENPP2, CLM3, CCL9, FCGRT, CCL5, IL7R, CD68, ITGB7, SFTPD, FCER1G, EMB, GPNMB, CD27, TYROBP, LPL, SELP, OVGP1, KLK8, LYZ2, CD8B1, PTPRZ1, PSAP, NID1, CHI3L3, HGF, IL6RA, CD55, EMR1, CXCL16, LIPH, MPO, LYG1 | | Regulation of apoptosis | LST1, NUAK2, MMP9, STK17B, TGFB3, GLI3, GPX1, TSC22D3, NOD1, APOE, BCL11B, TRP53INP1, FCER1G, LOC100047353, LTB, PIK3R1, RASA1, CD27, RAB27A, CD3G, HGF, SNAI2, ATP7A, NRP, ADRB2, MSX1, ERN2, PRNP | | Downregulation | Cell cycle | E2F1, RAD51C, CLSPN, PRC1, KNTC1, AURKA, AURKB, CCNE1, CDCA8, MCM7, SEH1L, OIP5, FANCI, INCENP, PSMC3IP, MTBP, CDCA2, RANBP1, H2AFX, TUBG1, CDCA5, ASPM, CDCA3, CDC6, KIF11, DSN1, SGOL2, LIG1, SGOL1, TPX2, MND1, NUSAP1, ESPL1, MCM2, MCM3, CDK4, ESCO2, 6720463M24RIK, RAD51, MCM6, NCAPD2, UHRF1, MAD2L1, TIMELESS, SPAG5, FANCD2, CCND2, BUB1B, LOC640972, SIAH2, STMN1, MAD2L2, NUP43, CCDC99, TIPIN, ANLN, CEP55, RCC1, C79407, SPC25, NCAPH, NCAPG2, F630043A04RIK, MNS1, TFDP1, CKAP2, MKI67, DLGAP5, GMNN, NASP, SYCE2, BIRC5, CDC20, NDC80, CDKN3, CENPH, CCNB1, PLK1, PHGDH, CHTF18, CHAF1A, CHAF1B | | Intracellular nonmembrane-bounded organelle | RPP38, PRC1, KNTC1, AURKA, AURKB, EBNA1BP2, TOP1, CDCA8, OIP5, INCENP, PRIM2, H2AFX, TUBG1, RPS27A, ASPM, NUP133, SGOL2, SGOL1, RRP9, MRTO4, NCAPD2, RSL1D1, PA2G4, MAD2L1, RFC4, SPAG5, STMN1, MYBBP1A, NUP43, HMGB2, CCDC99, BLM, LMNB1, NHP2L1, NOC3L, TIPIN, ANLN, BANF1, SPC25, ORC6L, HIST1H4F, MNS1, ASF1B, MRPS27, CKAP2, MRPS28, NOC4L, MKI67, MRPS22, SYCE2, NDC80, PLK4, NUP62, HIST1H3A, PCNA, HIST1H3C, DNMT1, HIST1H3D, HIST1H3E, TMPO, ZBTB32, CLSPN, KIF22, LYAR, MKI67IP, GTSE1, SLC1A4, KIF2C, HIST2H2AB, RRP1B, GRWD1, SEH1L, FANCI, RANBP1, TOP2A, FTSJ3, CDC6, KIF11, EXOSC6, DSN1, KIF15, EXOSC2, TPX2, NUSAP1, NUP85, MRPS6, MCM2, MID1IP1, POLR1B, LOC100047827, RAD51, APITD1, FANCD2, NOL10, BUB1B, NUP107, KPNA2, WDR43, 2610036L11RIK, MTDH, HIST1H2AG, TUBA3B, UTP6, DNAHC11, CEP55, FCF1, C79407, GPHN, KIF4, MRPL16, F630043A04RIK, MARS, CENPN, TCP1, CENPM, RRP12, DLGAP5, PNO1, CENPP, BIRC5, CENPK, CENPI, CENPH, CCNB1, HIST1H2AH, HIST1H2AK, MPHOSPH6 | | Chromosome | ZBTB32, CLSPN, KIF22, KNTC1, AURKB, HIST2H2AB, TOP1, CDCA8, OIP5, SEH1L, FANCI, INCENP, PRIM2, H2AFX, TUBG1, TOP2A, NUP133, DSN1, SGOL2, SGOL1, NUP85, MCM2, NCAPD2, LOC100047827, RAD51, MAD2L1, RFC4, APITD1, SPAG5, FANCD2, BUB1B, NUP107, NUP43, 2610036L11RIK, HMGB2, CCDC99, BLM, HIST1H2AG, TIPIN, BANF1, C79407, SPC25, F630043A04RIK, ORC6L, HIST1H4F, ASF1B, CENPN, CENPM, TCP1, MKI67, CENPP, SYCE2, NDC80, BIRC5, CENPK, CENPI, CENPH, HIST1H3A, PCNA, HIST1H2AH, DNMT1, HIST1H3C, HIST1H2AK, HIST1H3D, TMPO, HIST1H3E | | DNA metabolic process | CLSPN, KIF22, RAD51C, MCM10, CCNE1, TOP1, MCM7, FANCI, PRIM2, PSMC3IP, H2AFX, TOP2A, CDC6, NUDT1, POLH, LIG1, POLE, GTF2H4, MND1, MCM2, RBBP7, MCM3, ESCO2, MCM5, MCM6, RAD51, UHRF1, RFC4, FANCD2, RRM2, RRM1, LOC640972, AICDA, RUVBL2, HMGB2, BLM, UNG, TIPIN, BANF1, TK1, ORC6L, APEX1, FEN1, GINS1, GINS2, RAD51AP1, NASP, BRIP1, EEF1E1, POLD2, PCNA, DNMT1, CHTF18, CHAF1A, CHAF1B | | ATP binding | HSP90AB1, RAD51C, KIF22, NARS, FIGNL1, CTPS, AURKA, CAD, CCT3, AURKB, MTHFD1, DDX27, WARS, TOP1, KIF2C, MCM7, OASL1, MLKL, TOP2A, CDC6, KIF11, HSP90AA1, PFKL, LIG1, AARS, KIF15, PFKP, TBRG4, CCT6A, PBK, MCM2, MCM3, CDK4, GMPS, MCM5, TTF2, RAD51, MCM6, TARS, NME2, RFC4, PKM2, RARS, EIF4A1, RRM1, FARSB, BUB1B, RUVBL2, ALDH18A1, BLM, TRIB3, ASNS, DNAHC11, KARS, PFAS, TK1, IARS, GALK1, STK40, KIF4, LARS, HSPE1, UCK2, HSPA5, HSPA8, MARS, TCP1, PIF1, PDK3, DDX1, BRIP1, EPRS, AARSD1, LOC100046163, PSMB9, GART, HYOU1, CCT5, PLK4, PLK1, CHTF18, HSPD1, PGK1, PAICS | | Nucleotide binding | RAD51C, CTPS, HMGCR, AURKA, AURKB, CCT3, DDX27, TOP1, OASL1, MLKL, TUBG1, GBP6, LIG1, AARS, POLE, TBRG4, IFI47, NME2, RFC4, RARS, SNRPA, GBP3, GBP2, GBP1, BLM, KARS, TK1, GMPPB, EIF3B, GFM1, HSPE1, PIF1, DDX1, BRIP1, EPRS, AARSD1, VDAC2, VDAC3, LOC100046163, GART, PSMB9, HYOU1, CCT5, PLK4, PLK1, HSPD1, HSP90AB1, KIF22, NARS, FIGNL1, MKI67IP, CAD, MTHFD1, WARS, KIF2C, MCM7, SRPR, TOP2A, CDC6, KIF11, HSP90AA1, PFKL, KIF15, PFKP, CCT6A, GRHPR, PBK, MCM2, CDK4, ARL6, MCM3, GMPS, MCM5, TTF2, RAD51, MCM6, TARS, SQLE, PKM2, EIF4A1, RRM1, FARSB, BUB1B, THOC4, RUVBL2, ALDH18A1, TUBA3B, TRIB3, ASNS, DNAHC11, PFAS, IARS, GALK1, GPHN, STK40, KIF4, LARS, HSPA5, UCK2, GAPDH, HSPA8, MARS, TCP1, PDK3, PHGDH, CHTF18, PGK1, PAICS | | Membrane-enclosed lumen | E2F1, RPP38, PDIA3, LYAR, EZH2, PDIA6, MKI67IP, TOP1, EBNA1BP2, CDCA8, RRP1B, OIP5, GRWD1, TOP2A, FTSJ3, EXOSC6, GTF2H4, EXOSC2, NUSAP1, RRP9, POLR1B, CDK4, RBBP7, MRTO4, RSL1D1, PA2G4, TIMM8A1, C1QBP, JUN, NOL10, THOC4, RUVBL2, WDR43, MYBBP1A, MDH2, ALDOA, MTDH, LMNB1, NHP2L1, UTP6, NOC3L, TIMM10, CHCHD4, CALR, FCF1, KDELC1, SET, MRPL16, CACYBP, HSPE1, HSPA5, WDHD1, GEMIN6, TFDP1, MARS, RRP12, NOC4L, MKI67, MRPS22, PDK3, PNO1, ATF5, HYOU1, PLK4, ATF3, SDF2L1, PCNA, HSPD1, MPHOSPH6 | | Cellular response to stress | KIF22, CLSPN, HMGB2, BLM, UNG, TIPIN, MIF, FANCI, IFNG, BCL3, H2AFX, HSPA5, FAM129A, APEX1, FEN1, RAD51AP1, NUDT1, POLH, LIG1, AARS, POLE, GTF2H4, BRIP1, ESCO2, RAD51, UHRF1, NUPR1, TIMELESS, FANCD2, EEF1E1, PCNA, RUVBL2, LOC100044948, CHAF1A, CHAF1B |
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