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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 974256, 8 pages
http://dx.doi.org/10.1155/2013/974256
Review Article

Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Received 10 June 2013; Accepted 13 August 2013

Academic Editor: Angelo Antonio Izzo

Copyright © 2013 Shukranul Mawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [46 citations]

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  • Gulcin Tezcan, Berrin Tunca, Ahmet Bekar, Murat Yalcin, Saliha Sahin, Ferah Budak, Gulsah Cecener, Unal Egeli, Cevdet Demir, Gokcen Guvenc, Gozde Yilmaz, Leman Gizem Erkan, Hulusi Malyer, Mevlut Ozgur Taskapilioglu, Turkkan Evrensel, and Ayhan Bilir, “Ficus carica Latex Prevents Invasion Through Induction of Let-7d Expression in GBM Cell Lines,” Cellular and Molecular Neurobiology, 2014. View at Publisher · View at Google Scholar
  • Yanliang Wang, Hong Liang, Qingying Zhang, Wei Cheng, and Sirong Yi, “Phytochemical and chemotaxonomic study on Ficus tsiangii Merr. ex Corner,” Biochemical Systematics and Ecology, vol. 57, pp. 210–215, 2014. View at Publisher · View at Google Scholar
  • Melisa I. Barolo, Nathalie Ruiz Mostacero, and Silvia N. López, “Ficus carica L. (Moraceae): An ancient source of food and health,” Food Chemistry, vol. 164, pp. 119–127, 2014. View at Publisher · View at Google Scholar
  • Toru Takahashi, Aya Okiura, Keita Saito, and Masahiro Kohno, “ Identification of Phenylpropanoids in Fig ( Ficus carica L.) Leaves ,” Journal of Agricultural and Food Chemistry, pp. 141003103017007, 2014. View at Publisher · View at Google Scholar
  • Yang-Mei Zhang, Jian-Guang Luo, Lin Jing, and Ling-Yi Kong, “Tirucallane-Type triterpenoids from the fruit of Ficus carica and their cytotoxic activity,” Chemical and Pharmaceutical Bulletin, vol. 63, no. 3, pp. 237–243, 2015. View at Publisher · View at Google Scholar
  • Brankica Raskovic, Jelena Lazic, and Natalija Polovic, “ Characterisation of general proteolytic, milk clotting and antifungal activity of Ficus carica latex during fruit ripening ,” Journal of the Science of Food and Agriculture, 2015. View at Publisher · View at Google Scholar
  • Souhila Mahmoudi, Mustapha Khali, Abderahim Benkhaled, Karima Benamirouche, and Imen Baiti, “Phenolic and flavonoid contents, antioxidant and antimicrobial activities of leaf extracts from ten Algerian Ficus carica L. varieties,” Asian Pacific Journal of Tropical Biomedicine, 2015. View at Publisher · View at Google Scholar
  • Robert Veberic, and Maja Mikulic-Petkovsekpp. 235–255, 2015. View at Publisher · View at Google Scholar
  • Aneta Wojdyło, Paulina Nowicka, Ángel A. Carbonell-Barrachina, and Francisca Hernández, “Phenolic compounds, antioxidant and antidiabetic activity of different cultivars of Ficus carica L. fruits,” Journal of Functional Foods, vol. 25, pp. 421–432, 2016. View at Publisher · View at Google Scholar
  • Tea Knap, Jernej Jakše, Sara Cregeen, Branka Javornik, Matjaž Hladnik, and Dunja Bandelj, “Characterization and defining of a core set of novel microsatellite markers for use in genotyping and diversity study of Adriatic fig (Ficus carica L.) germplasm,” Brazilian Journal of Botany, 2016. View at Publisher · View at Google Scholar
  • Tina Ilc, Claire Parage, Benoît Boachon, Nicolas Navrot, and Danièle Werck-Reichhart, “Monoterpenol Oxidative Metabolism: Role in Plant Adaptation and Potential Applications,” Frontiers in Plant Science, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Brajesh Kumar, Kumari Smita, Luis Cumbal, and Alexis Debut, “ Ficus carica (Fig) Fruit Mediated Green Synthesis of Silver Nanoparticles and its Antioxidant Activity: a Comparison of Thermal and Ultrasonication Approach,” BioNanoScience, vol. 6, no. 1, pp. 15–21, 2016. View at Publisher · View at Google Scholar
  • Stavroula Mamoucha, Nikolas Fokialakis, and Nikolaos S. Christodoulakis, “Leaf structure and histochemistry of Ficus carica (Moraceae), the fig tree,” Flora - Morphology, Distribution, Functional Ecology of Plants, vol. 218, pp. 24–34, 2016. View at Publisher · View at Google Scholar
  • Gyory Hedvig, Blázovics Anna, and Katona Júlia, “Azon orvosságok kezdete, melyeket a májra adnak,” Orvosi Hetilap, vol. 157, no. 48, pp. 1926–1933, 2016. View at Publisher · View at Google Scholar
  • Hossein Karegar-Borzi, Mehdi Salehi, and Roja Rahimi, “Laūq: A Sustained-Release Dosage Form for Respiratory Disorders in Traditional Persian Medicine,” Journal of Evidence-Based Complementary and Alternative Medicine, vol. 21, no. 1, pp. 63–70, 2016. View at Publisher · View at Google Scholar
  • Shukranul Mawa, Ibrahim Jantan, and Khairana Husain, “Isolation of Terpenoids from the Stem of Ficus aurantiaca Griff and their Effects on Reactive Oxygen Species Production and Chemotactic Activity of Neutrophils,” Molecules, vol. 21, no. 1, pp. 9, 2016. View at Publisher · View at Google Scholar
  • Shirin Abbasi, Mohammad Kamalinejad, Delara Babaie, SeyedMohammad Shams, Zahra Sadr, Mehdi Gheysari, Vahid Reza Askari, and Hassan Rakhshandeh, “A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial,” Complementary Therapies in Medicine, vol. 35, pp. 85–91, 2017. View at Publisher · View at Google Scholar
  • Fadia S. Youssef, Rola M. Labib, Omayma A. Eldahshan, and Abdel Nasser B. Singab, “Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics,” Chemistry & Biodiversity, pp. e1700206, 2017. View at Publisher · View at Google Scholar
  • Maria Palassarou, Eleni Melliou, George Balayiannis, Prokopios Magiatis, Maria Liouni, and Antonios Michaelakis, “Volatile profile of Greek dried white figs (Ficus carica L.) and investigation of the role of β-damascenone in aroma formation in fig liquors,” Journal of the Science of Food and Agriculture, vol. 97, no. 15, pp. 5254–5270, 2017. View at Publisher · View at Google Scholar
  • Peng Wang, Li-Li Niu, Yu-Jie Fu, Tong Wang, Jiao Jiao, Qing-Yan Gai, and Na Guo, “Enhanced and green extraction polyphenols and furanocoumarins from Fig (Ficus carica L.) leaves using deep eutectic solvents,” Journal of Pharmaceutical and Biomedical Analysis, vol. 145, pp. 339–345, 2017. View at Publisher · View at Google Scholar
  • R. Orozco-Rodríguez, R. Chacón-Cerdas, J. Rosales-Flores, F. Arguello-Delgado, A. Schmidt-Durán, L. Alvarado-Marchena, C. Alvarado-Ulloa, and D. Flores-Mora, “ Description of the growth and development of the fig tree ( Ficus carica ) and its environmental interaction in Costa Rica ,” Acta Horticulturae, no. 1173, pp. 221–226, 2017. View at Publisher · View at Google Scholar
  • U. Aksoy, “The dried fig management and the potential for new products,” Acta Horticulturae, no. 1173, pp. 377–382, 2017. View at Publisher · View at Google Scholar
  • Marjan Mahjour, Arash Khoushabi, Maryam Miri Ghale Novi, and Zohre Feyzabadi, “Food strategies of renal atrophy based on Avicenna and conventional medicine,” Journal of Traditional and Complementary Medicine, 2017. View at Publisher · View at Google Scholar
  • Shuaibu Babaji Sanusi, Mohd Fadzelly Abu Bakar, Maryati Mohamed, Siti Fatimah Sabran, and Muhammad Murtala Mainasara, “Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–39, 2017. View at Publisher · View at Google Scholar
  • Sevin Teoman, Meryem Ipek, Umran Erturk, Nesrin Aktepe Tangu, Erdem Durgut, Erdogan Barut, Sezai Ercisli, and Ahmet Ipek, “Assessment of genetic relationship among male and female fig genotypes using simple sequence repeat (SSR) markers,” Notulae Botanicae Horti Agrobotanici Cluj-Napoca, vol. 45, no. 1, pp. 172–178, 2017. View at Publisher · View at Google Scholar
  • Jafarpour, Amirzadeh, Maleki, and Mahmoudi, “Comparison of physicochemical properties and general acceptance of flavored drinking yogurt containing date and fig syrups,” Foods and Raw Materials, vol. 5, no. 2, pp. 36–43, 2017. View at Publisher · View at Google Scholar
  • Yousef H. Aldebasi, and Arshad H. Rahmani, “Ficus carica and its constituents role in management of diseases,” Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 6, pp. 49–53, 2017. View at Publisher · View at Google Scholar
  • Kunle Okaiyeto, Uchechukwu U. Nwodo, Leonard V. Mabinya, and Anthony I. Okoh, “A review on some medicinal plants with hepatoprotective effects,” Pharmacognosy Reviews, vol. 12, no. 24, pp. 186–199, 2018. View at Publisher · View at Google Scholar
  • Sahar Sedaghat, and Majid Rahemi, “Effects of physio-chemical changes during fruit development on nutritional quality of fig ( Ficus carica L. var. ‘Sabz’) under rain-fed condition,” Scientia Horticulturae, vol. 237, pp. 44–50, 2018. View at Publisher · View at Google Scholar
  • Xian Lu, Guanqun Wo, Binghua Li, Chun Xu, Junhua Wu, Chunping Jiang, and Jiwu Wei, “The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma,” Biomedicine & Pharmacotherapy, vol. 102, pp. 420–427, 2018. View at Publisher · View at Google Scholar
  • Phan Minh Giang, and Hideaki Otsuka, “New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam,” Chemical and Pharmaceutical Bulletin, vol. 66, no. 5, pp. 493–505, 2018. View at Publisher · View at Google Scholar
  • Sakihito Kitajima, Wataru Aoki, Daisuke Shibata, Daisuke Nakajima, Nozomu Sakurai, Kazufumi Yazaki, Ryosuke Munakata, Toki Taira, Masaru Kobayashi, Shunsuke Aburaya, Eric Hyrmeya Savadogo, Susumu Hibino, and Haruna Yano, “Comparative multi-omics analysis reveals diverse latex-based defense strategies against pests among latex-producing organs of the fig tree (Ficus carica),” Planta, 2018. View at Publisher · View at Google Scholar
  • Margherita Rodolfi, Tommaso Ganino, Benedetta Chiancone, and Raffaella Petruccelli, “Identification and characterization of Italian common figs (Ficus carica) using nuclear microsatellite markers,” Genetic Resources and Crop Evolution, 2018. View at Publisher · View at Google Scholar
  • Jaculin Raiza Anasdass, Pandian Kannaiyan, Raghunathan Raghavachary, Subash C. B. Gopinath, and Yeng Chen, “Palladium nanoparticle-decorated reduced graphene oxide sheets synthesized using Ficus carica fruit extract: A catalyst for Suzuki cross-coupling reactions,” Plos One, vol. 13, no. 2, pp. e0193281, 2018. View at Publisher · View at Google Scholar
  • Emelia Oppong Bekoe, Cindy Kitcher, Nana Ama Mireku Gyima, Gladys Schwinger, and Mark Frempong, “Medicinal Plants Used as Galactagogues,” Pharmacognosy - Medicinal Plants [Working Title], 2018. View at Publisher · View at Google Scholar
  • Nur Qisya Afifah Veronica Sainik, Ayu Suraya Ansari, Abid Nordin, Aminuddin Bin Saim, Isa Naina-Mohamed, Ruszymah Bt Hj Idrus, Mohamed S. Zulfarina, and Rabiatul Adawiyah Razali, “Ficus carica and bone health: A systematic review,” Sains Malaysiana, vol. 47, no. 11, pp. 2741–2755, 2018. View at Publisher · View at Google Scholar
  • Mohd Zaid Ansari, and Weqar Ahmad Siddiqui, “Deoxygenation of graphene oxide using biocompatible reducing agent Ficus carica (dried ripe fig),” Journal of Nanostructure in Chemistry, 2018. View at Publisher · View at Google Scholar
  • Derya Aksu Demirezen, Yalçın Şevki Yıldız, Şeyda Yılmaz, and Dilek Demirezen Yılmaz, “Green synthesis and characterization of iron oxide nanoparticles using Ficus carica (common fig) dried fruit extract,” Journal of Bioscience and Bioengineering, 2018. View at Publisher · View at Google Scholar
  • Sita Sharan Patel, Ramsaneh Raghuwanshi, Misha Masood, Ashish Acharya, and Surendra Kumar Jain, “Medicinal plants with acetylcholinesterase inhibitory activity,” Reviews in the Neurosciences, no. 0, 2018. View at Publisher · View at Google Scholar
  • Ruhan Aşkın Uzel, “Impact of Ultrasound-Assisted Extraction on Supercritical Recovery of Valuable Compounds from Dry Pine Needles,” ETP International Journal of Food Engineering, pp. 8–13, 2018. View at Publisher · View at Google Scholar
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  • Azza M. Abdel-Aty, Abdul Aziz M. Gad, Amr E. El-Hakim, Mohamed Belal Hamed, and Saleh A. Mohamed, “Ficus sycomorus latex: An efficient alternative Egyptian source for horseradish peroxidase in labeling with antibodies for immunodiagnostic kits,” Veterinary World, vol. 11, no. 10, pp. 1364–1370, 2018. View at Publisher · View at Google Scholar
  • Badii Gaaliche, Afef Ladhari, Armando Zarrelli, and Mehdi Ben Mimoun, “Impact of foliar potassium fertilization on biochemical composition and antioxidant activity of fig (Ficus carica L.),” Scientia Horticulturae, vol. 253, pp. 111–119, 2019. View at Publisher · View at Google Scholar
  • Dalia Fouad, Hassah Alhatem, Rewaida Abdel-Gaber, and Farid Ataya, “Hepatotoxicity and renal toxicity induced by gamma-radiation and the modulatory protective effect of Ficus carica in male albino rats,” Research in Veterinary Science, 2019. View at Publisher · View at Google Scholar
  • Arshia Ghanbari, Adam Le Gresley, Declan Naughton, Nikolai Kuhnert, Diana Sirbu, and G. Hossein Ashrafi, “Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Yin Zhang, Yiming Zeng, Dandan Huang, Qiuxia Xu, and Jincheng Chen, “Involvement of AMPK activation in the inhibition of hepatic gluconeogenesis by Ficus carica leaf extract in diabetic mice and HepG2 cells,” Biomedicine and Pharmacotherapy, vol. 109, pp. 188–194, 2019. View at Publisher · View at Google Scholar