Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer Cells
Figure 1
Inhibition of hepatotoxicity in thiacremonone pretreated mice. (a) The survival rates in control, APAP-treated, and thiacremonone pretreated mice were monitored for 40 h after 500 mg/kg APAP i.p. injection (). Thiacremonone pretreated mice demonstrated significantly higher survival rates compared to APAP-treated mice by the log-rank test. The levels of ALT (b) and AST (c) were determined in untreated controls and 40 h after i.p. injection with 500 mg/kg APAP. Mice were pretreated with thiacremonone (10, 20, and 50 mg/kg) for 7 days before APAP treatment. Thiacremonone pretreated mice had a significant reduction in the levels of ALT and AST compared to APAP-treated mice. (d) Liver sections were analyzed by H&E stain. Data are mean ± SD; * indicates significant difference from control mice (); # indicates significant difference from APAP-treated mice ().
