Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis
Figure 1
Experimental details and the result of histological analysis by H&E staining of epidermal and dermal hyperplasia. (a) Experimental schedule of DNCB sensitization and acupuncture treatment at the local and meridian points. (b) Location of the acupuncture point LI11 used in this study. LI11 is in the depression on the lateral end of the cubital crease, at the midpoint of the line connecting LU5 with the lateral epicondyle of the humerus. (c) Reduced thickening and hyperplasia after acupuncture treatment at local and meridian points in the epidermis and dermis. Scale bar: 200 μm. (d-e) The skin thickness of the DNCB group was significantly increased compared to the normal group. Acupuncture treatment at the local points and meridian points significantly reduced thickening and hyperplasia in the epidermis (d) and dermis (e) compared to the DNCB group. NOR: mice treated with vehicle; DNCB: mice sensitized with DNCB; LP: mice sensitized with DNCB and treated at local points around the lesion; MP: mice sensitized with DNCB and treated at meridian point, LI11. , compared to the NOR group; , compared to the DNCB group. One-way ANOVA followed by the Newman-Keuls test was performed for statistical analysis, and all data are presented as the mean ± S.D.
