Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-𝜅B Activation in Streptozotocin-Induced Diabetic Rats

Table 2

Oxidant/antioxidant parameters as well as concentration of CML in the rat retina.

	Group  1	Group  2	Group  3	Group  4	Group  5
MDA, nmol/mg protein	2.45 ± 0.16	4.75 ± 0.17^a	3.98 ± 0.52^a,b	3.15 ± 0.25^a	2.95 ± 0.15^b
GST, nmol substrat·mg protein^−1·min^−1	176 ± 31	82 ± 13^a	105 ± 17^a,b	125 ± 11^a,b	151 ± 9^a,b
GSH-Px, nmol substrat·mg protein^−1·min^−1	0.92 ± 0.17	0.34 ± 0.09^a	0.55 ± 0.1^a,b	0.67 ± 0.15^a,b	0.82 ± 0.165^b
Catalase, IU·mg protein^−1	2.61 ± 0.032	0.52 ± 0.03^a	0.56 ± 0.02^a	0.96 ± 0.04^a,b	1.45 ± 0.21^a,b
SOD, nmol substrat·mg protein^−1·min^−1	3.53 ± 0.45	1.82 ± 0.35^a	1.92 ± 0.5^a	2.3 ± 0.6^a	2.95 ± 0.75^b
GSH, nmol/mg protein	16 ± 3	16.11 ± 2	16.1 ± 2.1	15.95 ± 2	16 ± 2.3
CML, pg/mg protein	3.54 ± 0.22	8.81 ± 0.34^a	5.42 ± 0.35^a,b	3.85 ± 0.55^b	3.2 ± 0.6^b

Data are expressed as the means ± SD. Group  1: normal control; group 2: diabetic untreated group; groups 3–5: diabetic groups treated with 5, 10, and 20% (W/W) oat in the diet, respectively. Each group consisted of 10 animals.
^a𝑃<0.05 versus normal control group, ^b𝑃<0.05 versus diabetic untreated group.