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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 985636, 6 pages
Research Article

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats

1Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi’an 710032, China
2The Surgery Department of 520th Hospital of PLA, Mian Yang 621000, China

Received 17 August 2013; Accepted 23 August 2013

Academic Editor: Bo Cui

Copyright © 2013 Wei Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats ( ). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.