Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats
Figure 5
Effect of TLN and α-LA on cell survival related genes in sciatic nerve of streptozotocin-induced rats. Relative expression level change () of 4 genes in qPCR, (a) Nrg1, (b) Pik3cb, (c) Mtor, and (d) Gab1. Statistical analysis was performed using the ANOVA procedure test (LSD). Data are expressed as mean ± SD. #, when compared with CTL group; *, when compared with STZ group. The mRNA expression of Nrg1, Pik3cb, Mtor, and Gab1 decreased compared with CTL group (); TLN intervention could increase the expression level of Nrg1, Mtor, and Gab1 compared with STZ group (). The alpha-lipoic acid intervention trend was consistent with Tang-Luo-Ning except Gab1. There were no significant differences of Pik3cb mRNA between the three groups (STZ, α-LA, and TLN). Four groups: CTL group: nonstreptozotocin-induced group, STZ group: streptozotocin-induced diabetic group, TLN group: Tang-Luo-Ning group, and α-LA group: alpha-lipoic acid group. ANOVA: analysis of variance; LSD- test: least significant difference test; qPCR: quantitative real time polymerase chain reaction.
