Review Article
Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
Table 1
Protection of mitochondria and improvement of energy metabolism during MIRI.
| Pharmacological action | Methods | Reference |
|
Protect mitochondria and improve energy metabolism | Reduce myocardial ATP delay ATP breakdown |
Nordlie et al. 2006 [5] | Protect Na+-K+-ATPase activity |
Wang et al. 2003 [6] | Stimulate synthesis of protein and RNA |
Zhu et al. 2010 [7] | Maintain the complete structure of biological membranes and myocardial fibers |
Shi et al. 1998 [8] | Reduce SDH and CCO deactivation |
Wang et al. 1998 [9] | Increase activity of Ca2+-ATPase and Ca2+-Mg2+-ATPase and regulate expression of the Bcl-2 gene |
Wan et al. 2001 [10] |
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