Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury

Table 1

Protection of mitochondria and improvement of energy metabolism during MIRI.

Pharmacological action	Methods	Reference
Protect mitochondria and improve energy metabolism	Reduce myocardial ATP delay ATP breakdown	Nordlie et al. 2006 [5]
	Protect Na^+-K^+-ATPase activity	Wang et al. 2003 [6]
	Stimulate synthesis of protein and RNA	Zhu et al. 2010 [7]
	Maintain the complete structure of biological membranes and myocardial fibers	Shi et al. 1998 [8]
	Reduce SDH and CCO deactivation	Wang et al. 1998 [9]
	Increase activity of Ca^2+-ATPase and Ca^2+-Mg^2+-ATPase and regulate expression of the Bcl-2 gene	Wan et al. 2001 [10]