Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans

Table 1

Fractional inhibitory concentrations (FIC) and indices (FICIs) of antifungal drugs fluconazole (FLC) and micafungin (MCFG) combined with the essential oil of Mentha suaveolens against Candida albicans.

	MICa	MICc	FIC	FICI
EOMS-fluconazole
M. suaveolens (mg/mL)	0.78	0.095	0.25	0.375
Fluconazole (𝜇g/mL)	2	0.5	0.125
EOMS-micafungin
M. suaveolens (mg/mL)	0.78	0.0243	0.031	0.531
Micafungin (𝜇g/mL)	0.0312	0.0156	0.5

MIC_a: MIC of the sample alone; MIC_c: MIC of the sample of the most effective combination. FIC of oil = MIC of oil in combination with antifungal drugs/MIC of oil alone. FIC of antifungal drug = MIC of antifungal drugs in combination with oil/MIC of antifungal drugs. FICI = FIC oil + FIC of antifungal drug.