Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial
Table 2
Clinical outcomes for participants with severe HFMD.
Variable
Conventional therapy group ()
Reduning injection combination therapy group ()
TCM formulas combination therapy group ()
value of three groups’ comparison
value of two groups’ comparison
Primary outcome
Major complications, (%)
5 (4.4)
3 (2.5)
3 (2.5)
0.890
Neurogenic pulmonary edema
0 (0)
1 (0.8)
1 (0.8)
0.626
Cerebral edema
2 (1.8)
2 (1.6)
1 (0.8)
0.803
Bacterial infection
2 (1.8)
0 (0)
1 (0.8)
0.335
Circulatory failure
1 (0.9)
0 (0)
0 (0)
0.343
Secondary outcome
Time to fever clearance, h (95% CI)
20 (6.0–25.0)
18 (4.0–24.0)
6 (4.0–16.0)
0.0493
0.048 (TCM group relative to conventional group)
Time to rash subsidence, days (95% CI)
7 (6.0-7.0)
6 (6.0-7.0)
7 (6.0-7.0)
0.667
HFMD-related mortality
0
0
0
1.000
Combined utilization of intracranial pressure-lowering drugs
77%
60.8%
68%
0.30
Combined utilization of sedatives, %
24.8%
11.5%
18.3
0.012
0.008 (Reduning group relative to conventional group)
