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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 145901, 13 pages
http://dx.doi.org/10.1155/2014/145901
Research Article

Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice

1Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias Extractivas, Instituto Politecnico Nacional, Avenida Instituto Politécnico Nacional S/N, Unidad Profesional Adolfo Lopez Mateos, 07708 Mexico D.F., Mexico
2Departamento de Alimentos, Escuela Nacional de Ciencias Biologicas, IPN Carpio S/N, 11340 Mexico D.F., Mexico
3Departamento de Biotecnología y Bioingenieria, CINVESTAV, Avenida IPN S/N, 07360 Mexico D.F., Mexico
4Departamento de Ciencias, Basicas Unidad Profesional de Biotecnologia IPN, Avenida Acueducto S/N, 07340 Mexico D.F., Mexico

Received 11 May 2013; Revised 21 November 2013; Accepted 27 November 2013; Published 9 January 2014

Academic Editor: Musa T. Yakubu

Copyright © 2014 Rosa Martha Perez Gutierrez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is one of the major factors to increase various disorders like diabetes. The present paper emphasizes study related to the antiobesity effect of Phalaris canariensis seeds hexane extract (Al-H) in high-fat diet- (HFD-) induced obese CD1 mice and in streptozotocin-induced mild diabetic (MD) and severely diabetic (SD) mice.AL-H was orally administered to MD and SD mice at a dose of 400 mg/kg once a day for 30 days, and a set of biochemical parameters were studied: glucose, cholesterol, triglycerides, lipid peroxidation, liver and muscle glycogen, ALP, SGOT, SGPT, glucose-6-phosphatase, glucokinase, hexokinase, SOD, CAT, GSH, GPX activities, and the effect on insulin level. HS-H significantly reduced the intake of food and water and body weight loss as well as levels of blood glucose, serum cholesterol, triglyceride, lipoprotein, oxidative stress, showed a protective hepatic effect, and increased HDL-cholesterol, serum insulin in diabetic mice. The mice fed on the high-fat diet and treated with AL-H showed inhibitory activity on the lipid metabolism decreasing body weight and weight of the liver and visceral adipose tissues and cholesterol and triglycerides in the liver. We conclude that AL-H can efficiently reduce serum glucose and inhibit insulin resistance, lipid abnormalities, and oxidative stress in MD and SD mice. Our results demonstrate an antiobesity effect reducing lipid droplet accumulation in the liver, indicating that its therapeutic properties may be due to the interaction plant components soluble in the hexane extract, with any of the multiple targets involved in obesity and diabetes pathogenesis.