Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 3

Review Article

The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism

Table 3

Herbal mixture for EM treatment in the literature.

Herbal mixture; sample/case number ( ) Control; sample number ( ) Total clinical effect rateModel usedTherapeutic effects and actions References

Xuefu Zhuyu decoction (XZD); Gestrinone Capsule; : 91.14% versus 91.07%Human studyAlleviate dysmenorrhoea
Shrink endometriotic lesion
XZD; Mifepristone Tablets; : 90.0% versus 70.0%Human studyAlleviate dysmenorrhoea [26]
XZD; : 93%; : 60%; : 12%Human studyAlleviate dysmenorrhoea
Promote pregnancy
XZD; Danazol; : 95.2% versus 75.0% 
in XZD: 23.6%
Human studyAlleviate dysmenorrhoea
Promote pregnancy
Xiaochaihu decoction (XCHD)DanazolSD rat modelCOX-2 P450arom Estradiol IL-8 TNF- MVD VEGF Fas protein↑ apoptosis↑ in ectopic endometrial tissues[29, 3337]
Qu Yi Kang (QYK)DanazolSD rat modelTXB2 IL-2, IL-6 VEGF ER[39, 40, 4244]
Yi Wei Ning (YWN); : 93.48% Human studyDysmenorrhoea alleviation
Shrink endometriotic lesion
YWNWistar rat modelFas/FasL↑ Bcl-2 Bax↑ apoptosis↑ COX-2 in ectopic endometrial tissues[46, 48, 51]
Yi Wei San (YWS)DanazolRabbit model6-keto-PGF l TXB2 Blood rheology↑ Vasoactive substances[51, 52]
Huoxue Xiaoyi decoction (HXD)SD rat modelICAM-1 MMP-9 VEGF AAA pathway Recurrence rate[54, 55]

Note: (Total effect rate) = all effective number of cases/total number of cases; effective case refers to the patients or animal models whose signs and symptoms have been improved after treatment; : dysmenorrhoea alleviation rate; : pregnancy rate.

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