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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 148730, 10 pages
http://dx.doi.org/10.1155/2014/148730
Research Article

Evaluating the Individualized Treatment of Traditional Chinese Medicine: A Pilot Study of N-of-1 Trials

1Department of Respiratory Disease, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
3Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8S 4K1

Received 12 June 2014; Revised 12 August 2014; Accepted 15 August 2014; Published 11 November 2014

Academic Editor: Hongcai Shang

Copyright © 2014 Haiyin Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

After three pairs of treatment with the bronchiectasis stabilization decoction and the syndrome differentiation decoction, the patient (case1) felt that the treatment was quite successful. However, the comparison in overall symptom score showed no statistically significant differences (Figure 1).

Although difference in overall symptom score between the two decoctions was not statistically significant (Figure 2), the absolute difference of the mean symptom score between the two decoctions in two pairs of trial ≥ 0.5 points.

The differences in overall symptom score of case 3 between the two decoctions were not statistically significant (Figure 3).

Table 1: All statistical analyses were performed using RStudio 0.98.953. One-sided paired Wilcoxon signed rank tests (superiority tests) were conducted to analyze the data in test and control drug of each case. It was also used for the data of total cases together. A P-value of less than 0.05 was considered statistically significant for each test. Although all the three patients showed various degree of improvement, no significant differences were found between individualized herbal decoction and control decoction on symptoms score, nor on 24 hours sputum volume.

  1. Supplementary Materials