Mulberry Extracts Alleviate A<i>β</i><sub>25–35</sub>-Induced Injury and Change the Gene Expression Profile in PC12 Cells

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Comparison</td><td align="center">Downregulated</td><td align="center">Upregulated</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left"><svg height="13.2498pt" id="M11" style="vertical-align:-3.571899pt" version="1.1" viewbox="-0.0498162 -9.6779 39.8171 13.2498" width="39.8171pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M686 28C612 35 607 44 591 112C563 234 541 360 519 489L489 666L457 658L147 121C100 40 89 36 24 28L17 0H240L250 28C168 34 159 41 190 101L262 237H482C495 180 503 137 510 91C517 47 514 35 441 28L433 0H677L686 28ZM475 280H285L429 541H431L475 280Z" id="g113-66"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="703" vert-adv-y="703"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,9.248,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z" id="g113-224"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="581" vert-adv-y="581"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,16.781,3.264)"><path d="M411 139C381 76 368 73 314 73H129L267 224C351 317 400 380 400 469C400 574 322 635 233 635C176 635 128 610 98 576L40 495L63 476C89 515 130 568 198 568C274 568 316 519 316 436C316 347 251 264 191 192C142 134 85 76 30 21V0H403C415 45 425 89 438 131L411 139Z" id="g190-243"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="465" vert-adv-y="465"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,21.286,3.264)"><path d="M130 550H367L393 615L386 623H101L63 323C82 331 123 342 165 342C275 342 328 277 328 188C328 107 283 40 201 40C141 40 99 72 78 91C69 99 59 98 51 91C39 81 30 67 29 58C28 48 33 37 46 24C60 10 104 -12 149 -12C203 -11 269 14 323 59C384 109 412 165 412 225C412 308 347 399 219 399C193 399 146 382 104 367L130 550Z" id="g190-161"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="454" vert-adv-y="454"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,25.592,3.264)"><path d="M469 201V252H50V201H469Z" id="g190-178"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="520" vert-adv-y="520"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,30.523,3.264)"><path d="M269 381C298 400 325 421 340 436C360 455 370 476 370 504C370 579 313 635 223 635H222C170 635 123 610 95 579L52 516L72 497C95 533 136 577 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height="13.2498pt" id="M12" style="vertical-align:-3.571899pt" version="1.1" viewbox="-0.0498162 -9.6779 30.529 13.2498" width="30.529pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z" id="g113-224"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="581" vert-adv-y="581"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,7.533,3.264)"><path d="M411 139C381 76 368 73 314 73H129L267 224C351 317 400 380 400 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transform="matrix(.0095,0,0,-0.0095,21.275,3.264)"><path d="M269 381C298 400 325 421 340 436C360 455 370 476 370 504C370 579 313 635 223 635H222C170 635 123 610 95 579L52 516L72 497C95 533 136 577 193 577C245 577 286 546 286 482C286 408 218 369 127 339L133 314C149 319 174 325 197 325C254 325 324 285 324 192C325 83 266 39 201 39C143 39 103 68 78 91C70 98 62 97 54 91C45 84 33 71 32 58C30 46 34 35 48 22C61 10 102 -12 148 -12C216 -12 410 57 410 225C410 298 357 362 269 379V381Z" id="g190-232"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="452" vert-adv-y="452"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,25.514,3.264)"><path d="M130 550H367L393 615L386 623H101L63 323C82 331 123 342 165 342C275 342 328 277 328 188C328 107 283 40 201 40C141 40 99 72 78 91C69 99 59 98 51 91C39 81 30 67 29 58C28 48 33 37 46 24C60 10 104 -12 149 -12C203 -11 269 14 323 59C384 109 412 165 412 225C412 308 347 399 219 399C193 399 146 382 104 367L130 550Z" id="g190-161"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="454" vert-adv-y="454"></glyph.data></g></svg>) versus  A<svg height="13.2498pt" id="M13" style="vertical-align:-3.571899pt" version="1.1" viewbox="-0.0498162 -9.6779 30.529 13.2498" width="30.529pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z" id="g113-224"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="581" vert-adv-y="581"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,7.533,3.264)"><path d="M411 139C381 76 368 73 314 73H129L267 224C351 317 400 380 400 469C400 574 322 635 233 635C176 635 128 610 98 576L40 495L63 476C89 515 130 568 198 568C274 568 316 519 316 436C316 347 251 264 191 192C142 134 85 76 30 21V0H403C415 45 425 89 438 131L411 139Z" id="g190-243"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="465" vert-adv-y="465"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,12.038,3.264)"><path d="M130 550H367L393 615L386 623H101L63 323C82 331 123 342 165 342C275 342 328 277 328 188C328 107 283 40 201 40C141 40 99 72 78 91C69 99 59 98 51 91C39 81 30 67 29 58C28 48 33 37 46 24C60 10 104 -12 149 -12C203 -11 269 14 323 59C384 109 412 165 412 225C412 308 347 399 219 399C193 399 146 382 104 367L130 550Z" id="g190-161"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="454" vert-adv-y="454"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,16.344,3.264)"><path d="M469 201V252H50V201H469Z" id="g190-178"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="520" vert-adv-y="520"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,21.275,3.264)"><path d="M269 381C298 400 325 421 340 436C360 455 370 476 370 504C370 579 313 635 223 635H222C170 635 123 610 95 579L52 516L72 497C95 533 136 577 193 577C245 577 286 546 286 482C286 408 218 369 127 339L133 314C149 319 174 325 197 325C254 325 324 285 324 192C325 83 266 39 201 39C143 39 103 68 78 91C70 98 62 97 54 91C45 84 33 71 32 58C30 46 34 35 48 22C61 10 102 -12 148 -12C216 -12 410 57 410 225C410 298 357 362 269 379V381Z" id="g190-232"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="452" vert-adv-y="452"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,25.514,3.264)"><path d="M130 550H367L393 615L386 623H101L63 323C82 331 123 342 165 342C275 342 328 277 328 188C328 107 283 40 201 40C141 40 99 72 78 91C69 99 59 98 51 91C39 81 30 67 29 58C28 48 33 37 46 24C60 10 104 -12 149 -12C203 -11 269 14 323 59C384 109 412 165 412 225C412 308 347 399 219 399C193 399 146 382 104 367L130 550Z" id="g190-161"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="454" vert-adv-y="454"></glyph.data></g></svg></td><td align="center">98</td><td align="center">55</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Up- (≥2-fold) and down- (≤2-fold) regulation in gene expression in PC12 cells after exposure to A<i>β</i><sub>25–35</sub> or pretreatment with ME for 24 h.

Evidence-Based Complementary and Alternative Medicine

tab1

Table 1

Table 1: Mulberry Extracts Alleviate A<i>β</i><sub>25–35</sub>-Induced Injury and Change the Gene Expression Profile in PC12 Cells 

Evidence-Based Complementary and Alternative Medicine

Mulberry Extracts Alleviate Aβ25–35-Induced Injury and Change the Gene Expression Profile in PC12 Cells

Table 1

Mulberry Extracts Alleviate Aβ_25–35-Induced Injury and Change the Gene Expression Profile in PC12 Cells