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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 151235, 8 pages
Research Article

Efficacy and Safety of Clearing Heat and Detoxifying Injection in the Treatment of Influenza: A Randomized, Double-Blinded, Placebo-Controlled Trial

1The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China
2The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 314 Anshanxi Road, Naikai District, Tianjin 300193, China
3Jiangsu Hospital of Integrated Traditional Chinese and Western Medicine, No. 100 Shizi Street, Hongshan Road, Nanjing 210028, China
4The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, No. 54 Youdian Road, Shangyou District, Hangzhou 310006, China
5Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530011, China

Received 22 June 2014; Revised 9 September 2014; Accepted 28 October 2014; Published 25 November 2014

Academic Editor: Hongcai Shang

Copyright © 2014 Yu Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the efficacy and safety of CHDI in the treatment of influenza infection. Method. A randomized double-blind, double dummy trial was conducted. Influenza patients with a positive influenza A rapid test diagnosis were randomized to receive CHDI or oseltamivir. Primary outcome was assessed by the median fever alleviation time and clearance time, and secondary outcome was total scores of influenza symptoms. Results. One hundred thirty-nine participants were screened and 34 had a RT-PCR laboratory confirmation of influenza virus infection. Fever alleviation time was 2.5 and 5 hours in CHDI and oseltamivir, respectively, and fever clearance time was 32.5 and 49 hours. The HR of fever alleviation and clearance time shows no significant difference between two groups. Total scores of influenza symptoms descended significantly in both groups after treatment and descended more in CHDI than oseltamivir on day 2. Similar to total symptoms severity score, fever severity score descend more significantly in CHDI than oseltamivir on day 2, and there were no differences on other symptoms. Conclusions. CHDI have a similar effect to oseltamivir in reducing the duration of influenza illness. CHDI was well tolerated, with no serious adverse events noted during the study period.