Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice

Figure 2

Effects of DHI on serum TNF-α levels, caspase-8 activity, and inflammatory mediators expressed in liver. Serum for measuring TNF-α level (a) was collected at 1 h after D-GalN/LPS injection. The mRNA expressions of IL-1β (b) and IL-6 (d) were analyzed by real-time RT-PCR. Caspase-8 (c) activity was determined in liver homogenates at 6 h after D-GalN/LPS injection using the commercial caspase-8 colorimetric assay kit. Data show mean ± SEM (𝑛=8). ^†𝑃<0.05 versus the control group; *𝑃<0.05 and **𝑃<0.01 versus the GalN/LPS group.

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