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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 179796, 8 pages
Research Article

Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment

1School of Acupuncture, Moxibustion and Tuina, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang, Beijing 100029, China
2Department of Traditional Chinese Medicine, Inner Mongolia People’s Hospital, No. 20 Zhao Wuda Road, Hohhot, Inner Mongolia Autonomous Region 010017, China
3Department of Traditional Chinese Medicine and Rehabilitation, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, Zhejiang 310009, China

Received 4 June 2014; Revised 15 September 2014; Accepted 17 September 2014; Published 30 October 2014

Academic Editor: Haruki Yamada

Copyright © 2014 Yuping Mo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models. Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Eighteen male Sprague-Dawley rats were randomly assigned into three groups: control, model, and EA groups. Rats were treated by EA once daily for 21 days. The results showed that body weight and sucrose consumption were significantly increased in EA group than in the model group. The crossing numbers and rearing numbers in the open field test significantly decreased in the model group but not in the EA group. And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels. The present study suggested that EA had antidepressant effects on UCMS model rats. The potential antidepressant effect may be related to upregulating Gal expression in hippocampus.