Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions
Figure 2
Effect of P. granatum ethanolic extract (Pg) and tramadol (TRA) 10 mg/kg, as positive control, on the hot plate and tail withdrawal latencies in alloxan-induced diabetic mice. (a) Hot plate latency: NORM: normal control mice (crossed-triangles, straight line); DIA + VEH: diabetic animals treated with vehicle as control (closed-squares, straight-line); positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg (solid-stars, dotted-line); DIA + Pg 25 mg/kg: diabetic animals treated with Pg 25 mg/kg (solid-circles, straight-line); DIA + Pg 50 mg/kg: diabetic animals treated with Pg 50 mg/kg (up-triangles, dashed-line); DIA + Pg 100 mg/kg: diabetic animals treated with Pg 100 mg/kg (right-triangles, dashed-dotted-line). (b) Tail withdrawal latency: NORM: normal control mice (crossed-triangles, straight line); DIA + VEH: diabetic animals treated with vehicle as control (closed-squares, straight-line); positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg (solid-stars, dotted-line); DIA + Pg 25 mg/kg: diabetic animals treated with Pg 25 mg/kg (solid-circles, straight-line); DIA + Pg 50 mg/kg: diabetic animals treated with Pg 50 mg/kg (up-triangles, dashed-line); DIA + Pg 100 mg/kg: diabetic animals treated with Pg 100 mg/kg (right-triangles, dashed-dotted-line). Data are expressed in mean ± SEM. “” means compared with vehicle. “” means compared with vehicle.
