Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions
Figure 4
Effect of F2 and TRA 10 mg/kg, as positive control, on the hot plate and tail withdrawal latencies in alloxan-induced diabetic mice. (a) Hot plate latency: NORM: normal control mice (crossed-triangles, straight line); DIA + VEH: diabetic animals treated with vehicle as control (closed-squares, straight-line); placebo F2: diabetic animals treated with placebo F2 200 mg/kg (crossed-squares, dashed-line); positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg (solid-stars, dotted-line); DIA + F2 50 mg/kg: diabetic animals treated with F2 50 mg/kg (solid-circles, straight-line); DIA + F2 100 mg/kg: diabetic animals treated with F2 100 mg/kg (up-triangles, dashed-line). DIA + Pg 200 mg/kg: diabetic animals treated with F2 200 mg/kg (right-triangles, dashed-dotted-line). (b) Tail withdrawal latency: NORM: normal control mice (crossed-triangles, straight line); DIA + VEH: diabetic animals treated with vehicle as control (closed-squares, straight-line); placebo F2: diabetic animals treated with placebo F2 200 mg/kg (crossed-squares, dashed-line); positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg (solid-stars, dotted-line). DIA + F2 50 mg/kg: diabetic animals treated with F2 50 mg/kg (solid-circles, straight-line); DIA + F2 100 mg/kg: diabetic animals treated with F2 100 mg/kg (up-triangles, dashed-line). DIA + F2 200 mg/kg: diabetic animals treated with F2 200 mg/kg (right-triangles, dashed-dotted-line). Data are expressed in mean ± SEM. “” means compared with vehicle. “” means compared with vehicle.
