Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

Table 1

Acute effect of P. granatum ethanolic extract (Pg), F1, F2, and gallic acid (GA) on blood glucose of alloxan-induced diabetic mice (n = 7).

Group	Dose (mg/kg)	Mean blood glucose concentration ± SEM (mg/dL)
		0 hr	0.5 hr	2 hr	6 hr
Diabetic control	—	202.79 ± 5.60	211.93 ± 4.50	214.21 ± 9.70	210.15 ± 7.30
GB	5	219.70 ± 3.70	223.64 ± 1.80	159.74 ± 2.10	130.64 ± 2.40**
Pg	25	218.29 ± 1.50	142.44 ± 2.80	181.56 ± 2.02	138.89 ± 1.45*
Pg	50	200.43 ± 2.10	240.93 ± 2.50	158.41 ± 2.60	131.96 ± 1.90*
Pg	100	249.92 ± 1.80	292.44 ± 2.80	228.56 ± 2.02	128.98± 1.54*
Placebo F1	200	208.10 ± 3.10	227.23 ± 2.10	222.62 ± 2.30	209.98 ± 2.90
F1	50	243.12 ± 1.30	158.44 ± 1.90	167.65 ± 2.10	144.33 ± 2.00*
F1	100	201.33 ± 1.70	130.44 ± 2.10	160.89 ± 2.90	120.77 ± 2.10*
F1	200	263.11 ± 2.90	139.56 ± 2.40	117.79 ± 2.80	125.33 ± 2.30*
Placebo F2	200	213.56 ± 3.10	202.17 ± 2.60	201.13 ± 2.80	229.56 ± 3.10
F2	50	211.55 ± 2.90	205.12 ± 1.30	146.82 ± 1.40	147.725 ± 2.80*
F2	100	214.65 ± 1.30	213.99 ± 1.90	186.83 ± 1.10	123.27 ± 1.20*
F2	200	240.44 ± 2.50	190.825 ± 1.90	172.165 ± 1.80	142.87 ± 2.20*
GA	3	201.29 ± 5.60	210.43 ± 4.50	213.71 ± 9.70	209.05 ± 7.30
GA	6	202.20 ± 3.70	222.14 ± 1.80	158.24 ± 2.10	129.14 ± 2.40**
GA	12	218.29 ± 1.50	142.44 ± 2.80	181.56 ± 2.02	138.89 ± 1.45*

SEM: standard error of the mean.
∗P < 0.05 significant from the control animals.
∗∗P < 0.01 significant from the control animals.