Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

Table 2

Subacute effect of Pg, F1, F2, and GA on blood glucose of alloxan-induced diabetic mice (n = 7).

Group	Dose (mg/kg)	Mean blood glucose concentration ± SEM (mg/dL)
		1st day	3rd day	5th day	8th day
Control	—	107.90 ± 2.50	109.80 ± 3.60	108.86 ± 3.20	117.50 ± 4.70
Diabetic control^a	—	202.79 ± 5.60***	211.93 ± 4.50***	214.91 ± 9.70***	210.55 ± 7.30***
GB^b	5	186.70 ± 3.70	179.53 ± 2.90	161.54 ± 2.40**	171.97 ± 3.10
Pg ^b	25	138.67 ± 2.60	87.54 ± 1.70	158.63 ± 2.30	135.50 ± 2.10**
Pg ^b	50	143.34 ± 1.90	119.67 ± 1.70	119.33 ± 1.90	119.10 ± 1.10**
Pg ^b	100	132.12 ± 1.30	112.98 ± 2.50	124.36 ± 2.60	111.50 ± 2.50*
Placebo F1	200	193.10 ± 3.10	212.66 ± 2.90	229.54 ± 2.80	226.33 ± 2.10
F1^b	50	144.11 ± 1.20	129.40 ± 1.60	130.66 ± 2.40	125.88 ± 3.10*
F1^b	100	120.33 ± 1.70	115.60 ± 2.40	128.65 ± 2.90	124.33 ± 3.20*
F1^b	200	125.21 ± 2.90	115.50 ± 3.10	108.40 ± 2.40	104.32 ± 1.90*
Placebo F2	200	229.33 ± 2.50	226.89 ± 2.90	204.98 ± 3.10	265.44 ± 2.90
F2^b	50	175.50 ± 2.50	119.90 ± 2.10	119.10 ± 1.30	118.50 ± 1.90*
F2^b	100	118.65 ± 1.30	128.10 ± 1.30	122.49 ± 2.40	117.65 ± 2.10*
F2^b	200	191.33 ± 3.90	94.54 ± 1.40	108.55 ± 3.40	107.43 ± 2.50*
GA^b	3	198.10 ± 1.90	208.00 ± 2.20	111.36 ± 3.30	101.88 ± 2.22*
GA^b	6	179.65 ± 3.10	134.66 ± 2.60	130.54 ± 2.90	98.23 ± 2.87*
GA^b	12	168.33 ± 2.90	140.50 ± 3.50	137.25 ± 2.70	118.55 ± 3.50*

SEM: standard error of the mean.
∗P < 0.05 significant from the control animals.
∗∗P < 0.01 significant from the control animals.
∗∗∗P < 0.001 significant from the control animals.
aCompared to vehicle control.
bCompared to diabetic control.