Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

Table 3

Subacute effect of Pg, F1, F2, and GA on body weights in alloxan-induced diabetic mice (n = 7).

Group	Dose (mg/kg)	Mean body weight ± SEM (gm)
		1st day	3rd day	5th day	8th day
Control	—	25.90 ± 0.50	26.00 ± 0.60	26.01 ± 0.97	26.62 ± 0.70
Diabetic control^a	—	28.68 ± 0.70	27.10 ± 0.20	27.15 ± 0.80	27.69 ± 0.50
GB^b	5	22.90 ± 0.70	28.17 ± 1.70	28.54 ± 0.40	30.37 ± 1.10*
Pg ^b	25	24.11 ± 2.60	27.70 ± 1.50	30.20 ± 1.60	30.40 ± 2.10**
Pg ^b	50	29.30 ± 1.90	29.20 ± 1.60	29.30 ± 1.80	31.50 ± 2.20**
Pg ^b	100	30.24 ± 2.60	30.40 ± 1.70	31.54 ± 3.90	31.98 ± 2.90*
Placebo F1	200	27.50 ± 2.10	27.50 ± 2.20	27.00 ± 2.40	26.88 ± 2.50
F1^b	50	31.11 ± 1.20	31.00 ± 1.50	31.10 ± 1.60	31.50 ± 1.90
F1^b	100	30.10 ± 1.40	29.50 ± 2.50	30.50 ± 2.40	31.70 ± 2.50*
F1^b	200	31.00 ± 1.90	29.00 ± 3.50	32.60 ± 2.90	33.80 ± 2.80*
Placebo F2	200	24.50 ± 2.50	24.45 ± 2.60	24.01 ± 2.50	23.60 ± 2.40
F2^b	50	27.30 ± 1.90	27.40 ± 1.80	27.5 ± 1.90	27.8 ± 2.00
F2^b	100	28.40 ± 1.40	28.5 ± 1.50	28.90 ± 1.60	30.25 ± 2.50*
F2^b	200	31.90 ± 1.90	32.00 ± 1.80	32.50 ± 1.90	33.11 ± 2.10*
GA^b	3	29.20 ± 1.20	30.30 ± 1.30	30.50 ± 1.10	32.05 ± 1.20*
GA^b	6	31.56 ± 1.10	32.67 ± 0.60	33.45 ± 1.00	34.10 ± 1.60*
GA^b	12	30.20 ± 1.20	30.30 ± 1.30	29.50 ± 1.50	30.56 ± 1.40

SEM: standard error of the mean.
∗P < 0.05 significant from the control animals.
aCompared to vehicle control.
bCompared to diabetic control.