Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions
Table 4
In vivo assessment of the antioxidant activity of Pg, F1, F2, and GA using catalase levels in serum of alloxan-induced diabetic mice (n = 7).
Group
Dose (mg/kg)
Catalase level ± SEM (kU/I)
1st day
3rd day
5th day
8th day
Control
—
41.00 ± 1.50
41.50 ± 1.60
40.86 ± 1.20
41.62 ± 1.70
Diabetic controla
—
21.67 ± 1.60***
20.93 ± 1.30***
24.01 ± 1.90***
25.55 ± 1.40***
GBb
5
22.60 ± 1.70
25.00 ± 1.70
31.54 ± 1.40*
32.37 ± 1.00**
Pg
b
25
22.33 ± 1.80
22.66 ± 1.60
24.26 ± 2.10*
26.60 ± 1.90**
Pg
b
50
20.44 ± 1.30
22.55 ± 1.90
26.22 ± 1.69*
27.10 ± 1.20**
Pg
b
100
23.33 ± 1.50
26.40 ± 2.10
27.63 ± 2.10*
29.50 ± 2.30*
Placebo F1
200
21.50 ± 2.80
20.77 ± 2.10
20.84 ± 2.80
20.33 ± 2.20
F1b
50
20.11 ± 1.20
21.40 ± 1.60
24.66 ± 2.40*
26.88 ± 3.10*
F1b
100
22.33 ± 1.70
23.42 ± 2.20
26.10 ± 2.70*
27.10 ± 2.90*
F1b
200
19.44 ± 2.10
23.66 ± 2.70
27.50 ± 2.50*
30.62 ± 1.60*
Placebo F2
200
22.54 ± 2.40
20.89 ± 2.80
20.89 ± 3.10
20.66 ± 2.80
F2b
50
24.44 ± 2.70
24.21± 2.00
25.40 ± 1.70*
26.40 ± 1.70
F2b
100
20.14 ± 1.30
19.40 ± 1.40
24.00 ± 2.10*
26.56 ± 2.20*
F2b
200
21.85 ± 3.10
24.54 ± 2.40
26.66 ± 3.40*
28.34 ± 2.40*
GAb
3
21.44 ± 1.60
20.11 ± 1.10
22.36 ± 1.60
23.22 ± 1.30
GAb
6
20.55 ± 1.50
22.78 ± 1.60
24.85 ± 1.80*
26.42 ± 0.80*
GAb
12
24.00 ± 1.80
22.30 ± 1.40
24.11 ± 1.10*
26.33 ± 1.20*
SEM: standard error of the mean. P < 0.05 significant from the control animals. P < 0.01 significant from the control animals. P < 0.001 significant from the control animals. Compared to vehicle control. Compared to diabetic control.
