Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 4

Research Article

Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

Table 4

In vivo assessment of the antioxidant activity of Pg, F1, F2, and GA using catalase levels in serum of alloxan-induced diabetic mice (n = 7).

GroupDose (mg/kg)Catalase level ± SEM (kU/I)
1st day3rd day5th day8th day

Control41.00 ± 1.5041.50 ± 1.6040.86 ± 1.2041.62 ± 1.70
Diabetic controla21.67 ± 1.60***20.93 ± 1.30***24.01 ± 1.90***25.55 ± 1.40***
GBb522.60 ± 1.7025.00 ± 1.7031.54 ± 1.40*32.37 ± 1.00**
Pg b2522.33 ± 1.8022.66 ± 1.6024.26 ± 2.10*26.60 ± 1.90**
Pg b5020.44 ± 1.3022.55 ± 1.9026.22 ± 1.69*27.10 ± 1.20**
Pg b10023.33 ± 1.5026.40 ± 2.1027.63 ± 2.10*29.50 ± 2.30*
Placebo F120021.50 ± 2.8020.77 ± 2.1020.84 ± 2.8020.33 ± 2.20
F1b5020.11 ± 1.2021.40 ± 1.6024.66 ± 2.40*26.88 ± 3.10*
F1b10022.33 ± 1.7023.42 ± 2.2026.10 ± 2.70*27.10 ± 2.90*
F1b20019.44 ± 2.1023.66 ± 2.7027.50 ± 2.50*30.62 ± 1.60*
Placebo F220022.54 ± 2.4020.89 ± 2.8020.89 ± 3.1020.66 ± 2.80
F2b5024.44 ± 2.7024.21± 2.0025.40 ± 1.70*26.40 ± 1.70
F2b10020.14 ± 1.3019.40 ± 1.4024.00 ± 2.10*26.56 ± 2.20*
F2b20021.85 ± 3.1024.54 ± 2.4026.66 ± 3.40*28.34 ± 2.40*
GAb321.44 ± 1.6020.11 ± 1.1022.36 ± 1.6023.22 ± 1.30
GAb620.55 ± 1.5022.78 ± 1.6024.85 ± 1.80*26.42 ± 0.80*
GAb1224.00 ± 1.8022.30 ± 1.4024.11 ± 1.10*26.33 ± 1.20*

SEM: standard error of the mean.
P < 0.05 significant from the control animals.
P < 0.01 significant from the control animals.
P < 0.001 significant from the control animals.
Compared to vehicle control.
Compared to diabetic control.

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