In Vivo Antioxidant and Anti-Skin-Aging Activities of Ethyl Acetate Extraction from Idesia polycarpa Defatted Fruit Residue in Aging Mice Induced by D-Galactose

Table 2

Antioxidants status in the tissue and blood of mice in each group.

Index	Group^C	Brain	Liver	Kidney	Serum
MDA (nmol/mg prot or nmol/mL)	Model	7.09±1.27	4.31±1.10	5.07±0.71	7.07±0.58
	Control	5.47±0.62^a	2.23±0.97^a	3.89±0.51^a	5.21±0.58^a
	VC	4.87±0.94^b	2.27±0.36^b	3.80±0.68^a	4.92±0.22^a
	Low dose	5.53±0.39^a	3.21±1.15	4.76±0.77	5.11±0.70^a
	Medium dose	4.77±0.51^b#	2.57±0.48^a	3.61±0.80^b	4.73±0.20^a
	High dose	4.16±0.50^b##	2.03±0.63^b	2.87±0.53^bA#	5.44±0.63^a
SOD (U/mg prot or U/mL)	Model	139.29±17.74	281.25±31.04	153.42±5.21	96.64±4.39
	Control	211.64±38.02^b	368.10±35.78^b	195.91±16.30^b	121.70±9.45^a
	VC	181.12±29.52^b	384.02±27.66^b	145.91±16.87^##	131.65±13.05^a
	Low dose	158.62±21.84^a#	349.21±34.90^aA	171.10±14.59^aA#	96.41±10.65^A
	Medium dose	167.80±33.06^a#	353.29±22.14^bA	184.68±13.35^bB	102.26±5.46^A#
	High dose	175.24±22.22^b#	320.61±35.27^aB#	189.27±14.75^bB	115.62±8.24^a
GSH (mgGSH/g prot or mgGSH/L)	Model	2.96±0.70	1.10±0.20	1.52±0.25	6.81±0.58
	Control	5.59±0.86^b	1.72±0.10^b	2.53±0.16^b	12.56±0.40^b
	VC	3.93±0.45^a##	1.59±0.19^a	2.29±0.26^b	7.68±0.38^##
	Low dose	4.52±0.86^a#	1.30±0.33^#	1.63±0.35^B##	7.62±0.34^##
	Medium dose	5.83±0.66^bB	1.56±0.35^b	1.99±0.29^b#	7.98±0.21^a##
	High dose	7.09±0.98^bB#	2.32±0.33^bB##	2.52±0.33^b	9.17±0.42^bA##
GSH-Px (U/mg prot or U/mL)	Model	×	415.35±47.62	114.84±8.83	459.67±27.24
	Control		657.42±53.53^b	174.17±11.01^b	680.33±21.51^b
	VC		511.67±23.93^b##	159.10±16.63^b	626.41±16.88^b#
	Low dose		430.81±42.50^B##	151.54±21.95^b#	508.21±20.52^aB##
	Medium dose		602.80±67.82^bB#	169.50±16.33^b	650.73±14.10^bA
	High dose		493.69±34.11^b##	194.91±20.63^bB#	576.38±14.50^bA##
CAT (U/g prot or U/mL)	Model	×	295.67±36.16	120.01±13.85	5.42±0.29
	Control		340.24±34.51^a	166.53±34.24^b	9.71±0.70^b
	VC		394.63±62.56^b	149.67±29.17^a	12.91±1.19^b
	Low dose		317.88±22.79^A	148.28±24.34^a	8.61±0.47^bB
	Medium dose		403.77±41.93^b#	233.29±42.72^bB#	9.67±0.20^bA
	High dose		522.61±31.60^bB##	158.70±24.30^a	11.42±0.27^b#
T-AOC (U/mg prot or U/mL)	Model	0.83±0.21	1.23±0.10	0.59±0.06	4.56±0.39
	Control	1.41±0.28^b	1.66±0.17^b	1.00±0.15^b	6.52±0.28^b
	VC	2.48±0.23^b##	1.36±0.22^#	0.46±0.08^##	6.78±0.04^b
	Low dose	1.38±0.22^bB	1.34±0.10^#	1.18±0.08^bB#	5.38±0.23^aA#
	Medium dose	1.53±0.24^bB	1.58±0.16^b	1.25±0.11^bB#	5.85±0.26^bA#
	High dose	1.92±0.15^bB##	1.88±0.16^bB#	1.48±0.13^bB##	6.31±0.30^b

Values are the mean ± SD.
× means undetected.
^a𝑃<0.05; ^b𝑃<0.01 compared with model group (all groups). ^A𝑃<0.05; ^B𝑃<0.01 compared with VC group (EAE groups). ^#𝑃<0.05; ^##𝑃<0.01 compared with control group (VC and EAE groups). ^CVC group (100 mg/kg); low dose EAE group (100 mg/kg); medium dose EAE group (200 mg/kg); high dose EAE group (400 mg/kg).