Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats

Table 2

Hematological parameters of rats treated orally with PM014 for 13 weeks.

Hematological parameters	PM014 (mg/kg/day)
	0	750	1500	3000
Males
RBC (10^6/μL)	8.98±0.33	9.25±0.55	8.93±0.24	8.93±0.29
HGB (g/dL)	15.7±0.6	15.5±0.9	15.3±0.4	15.4±0.5
HCT (%)	47.6±1.9	47.1±2.5	46.3±1.3	46.9±1.6
MCV (fL)	53.0±1.7	51.1±3.6	51.9±1.5	52.6±1.6
MCH (pg)	17.5±0.5	16.8±1.4	17.1±0.5	17.2±0.6
MCHC (g/dL)	33.0±0.3	32.9±0.6	32.9±0.4	32.8±0.4
RDW (%)	12.4±0.3	12.8±0.4	12.6±0.4	12.3±0.3
HDW (g/dL)	2.50±0.11	2.57±0.09	2.57±0.12	2.54±0.20
RET (%)	2.34±0.28	2.37±0.32	2.48±0.41	2.59±0.31
PLT (10^3/μL)	934.9±60.3	1018.8±60.5	978.3±92.7	1001.9±102.2
MPV (fL)	4.7±0.1	4.7±0.2	4.7±0.1	4.8±0.2
WBC (10^3/μL)	7.98±1.40	10.06±1.72^∗∗	9.09±1.74	10.07±1.42^∗∗
NEU (%)	22.5±4.9	22.9±4.5	20.8±4.4	19.8±7.6
LYM (%)	70.6±5.3	70.1±5.3	72.5±5.0	73.9±7.3
MONO (%)	4.72±1.21	4.95±1.24	4.90±1.34	4.62±0.78
EOS (%)	1.60±0.49	1.51±0.45	1.17±0.49	1.15±0.49
BASO (%)	0.16±0.05	0.17±0.05	0.19±0.03	0.19±0.06
LUC (%)	0.34±0.16	0.37±0.12	0.37±0.12	0.40±0.24
PT (sec)	8.90±0.28	8.87±0.18	8.82±0.24	8.87±0.23
APTT (sec)	18.3±0.6	18.3±0.7	18.0±0.9	18.1±0.6
Females
RBC (10^6/μL)	7.88±0.17	7.77±0.22	7.79±0.22	7.62±0.36
HGB (g/dL)	14.8±0.3	14.2±0.3	14.4±0.4	14.0±0.7^∗
HCT (%)	43.5±1.1	41.8±0.9^∗∗	42.5±0.8	41.6±2.0
MCV (fL)	55.2±0.8	53.8±1.3	54.6±1.1	54.6±1.4
MCH (pg)	18.8±0.3	18.3±0.3^∗	18.5±0.5	18.4±0.3
MCHC (g/dL)	34.0±0.3	33.9±0.5	33.8±0.7	33.8±0.7
RDW (%)	11.4±0.2	11.0±0.3	11.2±0.3	11.1±0.4
HDW (g/dL)	2.51±0.12	2.34±0.14	2.35±0.17	2.33±0.10^∗
RET (%)	3.16±0.45	2.56±0.48	2.87±0.49	2.98±0.96
PLT (10^3/μL)	1105.3±95.7	1137.4±113.6	1128.8±154.8	1094.3±112.5
MPV (fL)	4.7±0.1	4.9±0.2	5.0±0.4	4.9±0.2
WBC (10^3/μL)	4.93±1.01	5.39±2.03	5.26±0.54	4.90±1.03
NEU (%)	12.4±4.0	18.2±8.4	14.9±2.8	15.8±6.3
LYM (%)	80.5±4.9	74.9±9.0	77.0±3.8	77.8±6.5
MONO (%)	4.80±1.23	4.91±1.02	5.88±1.35	4.34±0.93
EOS (%)	1.72±0.66	1.45±0.34	1.72±0.35	1.52±0.62
BASO (%)	0.13±0.07	0.08±0.06	0.12±0.09	0.11±0.06
LUC (%)	0.37±0.11	0.40±0.13	0.47±0.13	0.46±0.08
PT (sec)	9.00±0.28	9.06±0.27	8.99±0.27	9.15±0.26
APTT (sec)	17.9±0.7	17.9±1.1	18.5±0.7	17.9±0.5

RBC: red blood cell; HGB: haemoglobin concentration; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; HDW: Hb concentration distribution width; RET: reticulocytes; PLT: platelet; MPV: mean platelet volume; WBC: white blood cells; NEU: neutrophil; LYM: lymphocyte; MONO: monocyte; EOS: eosinophil; BASO: basophil; LUC: large unstained cells; PT: prothrombin time; APTT: activated partial thromboplastin time. The data shown are the means ± SD (𝑛=10/group). ^∗𝑃<0.05, ^∗∗𝑃<0.01 compared with the control group.