Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats

Table 4

Relative organ weights of rats treated orally with PM014 for 13 weeks.

Relative organ weights (%)	PM014 (mg/kg/day)
	0	750	1500	3000
Males
Adrenal gland, left	0.0058±0.0006	0.0063±0.0007	0.0059±0.0009	0.0062±0.0011
Adrenal gland, right	0.0056±0.0006	0.0061±0.0006	0.0057±0.0007	0.0060±0.0010
Pituitary gland	0.0027±0.0003	0.0029±0.0003	0.0029±0.0003	0.0029±0.0003
Thymus	0.0712±0.0151	0.0767±0.0191	0.0703±0.0093	0.0731±0.0215
Prostate gland	0.1347±0.0358	0.1664±0.0347	0.1273±0.0369	0.1532±0.0238
Testis, left	0.4398±0.1099	0.4890±0.0398	0.4665±0.0373	0.4437±0.0266
Testis, right	0.4731±0.0310	0.4836±0.0309	0.4644±0.0316	0.4561±0.0275
Epididymis, left	0.1500±0.0300	0.1667±0.0163	0.1490±0.0140	0.1474±0.0119
Epididymis, right	0.1560±0.0092	0.1661±0.0107	0.1487±0.0121	0.1530±0.0126
Spleen	0.1858±0.0158	0.1923±0.0260	0.2047±0.0304	0.2165±0.0234
Kidney, left	0.3012±0.0170	0.3182±0.0233	0.2956±0.0143	0.3064±0.0174
Kidney, right	0.3119±0.0219	0.3288±0.0282	0.3064±0.0151	0.3151±0.0123
Heart	0.3247±0.0304	0.3308±0.0313	0.3267±0.0254	0.3348±0.0360
Lung	0.4083±0.0226	0.4148±0.0426	0.4091±0.0359	0.3977±0.0290
Brain	0.4404±0.0196	0.4456±0.0338	0.4381±0.0256	0.4316±0.0413
Liver	2.5858±0.1432	2.6340±0.1517	2.6295±0.1530	2.8191±0.1575^∗∗
Females
Ovary, left	0.0177±0.0024	0.0179±0.0026	0.0181±0.0019	0.0158±0.0026
Ovary, right	0.0190±0.0029	0.0191±0.0028	0.0189±0.0019	0.0178±0.0021
Adrenal gland, left	0.0120±0.0019	0.0131±0.0019	0.0128±0.0016	0.0121±0.0015
Adrenal gland, right	0.0116±0.0010	0.0129±0.0019	0.0121±0.0016	0.0115±0.0013
Pituitary gland	0.0054±0.0003	0.0059±0.0007	0.0056±0.0004	0.0056±0.0006
Thymus	0.1142±0.0186	0.1012±0.0171	0.0977±0.0215	0.1014±0.0241
Uterus	0.3232±0.1417	0.2807±0.0870	0.3351±0.1752	0.2860±0.1053
Spleen	0.2424±0.0174	0.2426±0.0234	0.2447±0.0434	0.2348±0.0290
Kidney, left	0.2931±0.0160	0.2977±0.0139	0.2951±0.0185	0.3005±0.0149
Kidney, right	0.3087±0.0079	0.3090±0.0157	0.3381±0.1099	0.3163±0.0139
Heart	0.3746±0.0292	0.3758±0.0168	0.3837±0.0159	0.3788±0.0253
Lung	0.5589±0.0299	0.5108±0.1637	0.5573±0.0435	0.5550±0.0334
Brain	0.7315±0.0587	0.7327±0.0283	0.7397±0.0518	0.7559±0.0447
Liver	2.4427±0.2687	2.5962±0.1578	2.4736±0.1612	2.4241±0.1368

Relative organ weight was calculated using the following formula: organ-body index (%) = wet organ weight/body weight × 100%. The data shown are the means ± SD (𝑛=10/group).
^∗∗𝑃<0.01 compared with the control group.