Current Studies of Acupuncture in Cancer-Induced Bone Pain Animal Models

Table 3

Outcome measures.

Reference	Behavior			Macroscopicfeatures	Histological and biochemical measures (site)
	Mechanical stimulus evoked	Heat stimulus evoked	Movement related
[15]	Hind paw withdrawal (von Frey filaments)			Bone surface; Bone destruction (X-ray)
[20]		Paw withdrawal latency (thermal sensitivity to radiant heat)			IL-1; (spinal cord)
[21]	Hind paw withdrawal pressure threshold (PWPT)	Paw withdrawal latency (thermal sensitivity to radiant heat)			PPD mRNA,  Dynorphin; (spinal cord)
[18]		Paw withdrawal latency (thermal sensitivity to radiant heat)		Bone surface; Bone destruction (X-ray)	GFAP; (spinal cord)
[22]	Hind paw withdrawal (von Frey filaments)	Cumulative lifting duration	Clear lifting and flinching	Tumor size and volume (MRI scanning)	Substance P; (spinal cord); -endorphin; (brain)

IL-, interleukin-; PPD, preprodynorphin; GFAP, glial fibrillary acidic protein.