Akebia trifoliate (Thunb.) Koidz Seed Extract Inhibits the Proliferation of Human Hepatocellular Carcinoma Cell Lines via Inducing Endoplasmic Reticulum Stress

Figure 1

ATSE cause different morphological changes in HCC cell lines. G418 (0.45 mg/mL), ATSE: Akebia trifoliate seed extract (0.625 mg/mL), and 1/2(G418 + ATSE): a combination of half dosage of each accordingly. (a–d) Images of HepG2 cells after different treatments, (e–h) images of HuH7 cells after different treatments, and (i–l) images of SMMC-7721 cells after different treatments. White arrowhead means different degree of ER expansion within cells. These images were taken under the 400x inverted phase contrast microscope.

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