Akebia trifoliate (Thunb.) Koidz Seed Extract Inhibits the Proliferation of Human Hepatocellular Carcinoma Cell Lines via Inducing Endoplasmic Reticulum Stress

Table 2

List of ER stress-related genes with significant expression in HuH7 cells (fold change ≥1.5-fold).

Probe set ID	Gene symbol	Control	G418	ATSE	1/2(G418 + ATSE)	ATSE/control
7954196	MGST1	479	815	1026	720	2.14
8024754	CREB3L3	171	55	353	69	2.06
7967563	UBC	2502	4281	4550	7132	1.82
7981335	HSP90AA1	1153	3916	1725	3257	1.50
8114455	HSPA9	1116	1499	749	1115	−1.50
7949383	SYVN1	326	235	208	224	−1.57
7964460	DDIT3	239	137	151	332	−1.58
8125295	ATF6B	202	49	117	82	−1.73
8080084	MANF	268	490	152	351	−1.77
8075182	XBP1	820	705	448	596	−1.83
8091458	SERP1	561	1050	303	635	−1.85
8137526	INSIG1	214	356	114	290	−1.88
7916432	DHCR24	2595	560	1278	280	−2.03
8138108	KDELR2	1272	1329	622	605	−2.04
8160914	VCP	423	764	200	227	−2.11
7989619	PPIB	1939	2258	917	2377	−2.11
8066889	STAU1	398	248	187	98	−2.12
8128111	UBE2J1	474	344	199	183	−2.38
7916120	TXNDC12	817	404	330	172	−2.48
7958644	ATP2A2	492	570	186	206	−2.65
8026106	CALR	1329	1694	497	1060	−2.67
8051998	MCFD2	411	507	149	213	−2.76
7995895	HERPUD1	915	870	297	960	−3.08
8084634	DNAJB11	279	947	89	529	−3.14
7906819	ATF6	268	361	80	174	−3.33
8041967	ERLEC1	275	363	77	109	−3.57
8128650	SEC63	982	1218	265	504	−3.71
8135480	DNAJB9	256	431	53	351	−4.86
7952145	HYOU1	492	757	97	266	−5.06
7956593	OS9	1008	857	195	383	−5.17
8046759	DNAJC10	452	202	77	27	−5.87
8023561	LMAN1	941	1298	159	448	−5.93
7980547	SEL1L	333	295	46	68	−7.27
8164165	GRP78	1834	2581	241	1442	−7.62
7904881	PDIA3P	1192	1261	131	644	−9.11
7958130	HSP90B1	1813	2793	198	1396	−9.17
7983274	PDIA3	1181	1226	119	602	−9.95
8095628	ALB	3131	1860	63	435	−49.59

G418 (0.45 mg/mL); ATSE: Akebia trifoliate seed extract (0.625 mg/mL); 1/2(G418 + ATSE): a combination of half dose of each accordingly.