Akebia trifoliate (Thunb.) Koidz Seed Extract Inhibits the Proliferation of Human Hepatocellular Carcinoma Cell Lines via Inducing Endoplasmic Reticulum Stress

Table 3

List of ER stress-related genes with significant expression in SMMC-7721 cells (fold change ≥1.5-fold).

Probe set ID	Gene symbol	Control	G418	ATSE	1/2(G418 + ATSE)	ATSE/control
7964460	DDIT3	106	274	525	546	4.94
8076481	CYB5R3	262	209	539	279	2.06
8139003	HERPUD2	186	263	323	271	1.74
8042107	VRK2	536	973	884	1075	1.65
8156838	SEC61B	299	566	469	638	1.57
8128650	SEC63	776	954	522	653	−1.50
8062174	ERGIC3	984	1042	662	686	−1.50
7958644	ATP2A2	575	769	382	536	−1.50
7989619	PPIB	1595	2090	989	2036	−1.61
8084634	DNAJB11	323	442	196	535	−1.62
7981335	HSP90AA1	1428	2906	831	2147	−1.72
8178498	HLA-B	327	268	190	246	−1.72
7958130	HSP90B1	1426	2138	744	2022	−1.92
8091954	GOLIM4	641	378	329	364	−1.95
7983274	PDIA3	855	1271	437	949	−1.96
8023561	LMAN1	735	816	372	690	−1.98
7904881	PDIA3P	889	1360	440	980	−2.02
8164165	GRP78	1317	2308	580	2346	−2.27
8160914	VCP	333	318	114	278	−2.91

G418 (0.45 mg/mL); ATSE: Akebia trifoliate seed extract (0.625 mg/mL); 1/2(G418 + ATSE): a combination of half dose of each accordingly.