Antihyperglycemic and Anti-Inflammatory Effects of Standardized Curcuma xanthorrhiza Roxb. Extract and Its Active Compound Xanthorrhizol in High-Fat Diet-Induced Obese Mice

Figure 1

Effects of XAN and CXE treatments on fasting glucose levels in HFD-induced obese mice. (a) Chemical structure of XAN. (b) Changes in fasting blood glucose levels. Mice were administrated normal diet (ND) for 24 weeks. After 8 weeks of HFD-induced obesity, mice were orally administrated with a vehicle HFD (HFD control), HFD with metformin 100 mg/kg/day (Met 100), XAN 10 or 25 mg/kg/day (XAN 10 or 25), or CXE 50 or 100 mg/kg/day (CXE 50 or 100) for 16 weeks. Results are expressed as mean ± SD (𝑛=7). ^##𝑃<0.01 compared to the ND group. ^∗∗𝑃<0.01 compared to the HFD control group.

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