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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 236310, 10 pages
http://dx.doi.org/10.1155/2014/236310
Research Article

Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study

1Research Institute Havelhoehe, 14089 Berlin, Germany
2Hospital Havelhoehe, 14089 Berlin, Germany
3Institute for Social Medicine, Epidemiology and Health Economics, Charité-University Medical Centre, 10117 Berlin, Germany
4Institute of Integrative Medicine, Witten/Herdecke University, 58313 Herdecke, Germany

Received 21 November 2013; Revised 2 April 2014; Accepted 3 April 2014; Published 15 May 2014

Academic Editor: Srini Kaveri

Copyright © 2014 Megan L. Steele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [20 citations]

The following is the list of published articles that have cited the current article.

  • Danijel Galun, Wilfried Tröger, and Miroslav Milicevic, “Cancer surgery and supportive mistletoe therapy: From scepticism to randomised clinical trials,” Translational Research in Biomedicine, vol. 4, pp. 57–66, 2015. View at Publisher · View at Google Scholar
  • Megan Steele, Jan Axtner, Matthias Kroez, Harald Matthes, and Friedemann Schad, “Adverse drug reactions to therapy with European Mistletoe Viscum album L.,” Phytomedicine, vol. 22, pp. S17–S18, 2015. View at Publisher · View at Google Scholar
  • H.W. Zhang, Z.X. Lin, and K. Chan, “Treatments Used in Complementary and Alternative Medicine,” 2015. View at Publisher · View at Google Scholar
  • Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes, and Friedemann Schad, “Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer,” BMC Cancer, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Marc Schläppi, Christoph Ewald, Jürgen Johannes Kuehn, Tomas Weinert, and Roman Huber, “Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study,” Integrative Cancer Therapies, vol. 16, no. 4, pp. 479–484, 2016. View at Publisher · View at Google Scholar
  • Peter Heusserpp. 1–368, 2016. View at Publisher · View at Google Scholar
  • Friedemann Schad, Jan Axtner, Matthias Kröz, Harald Matthes, and Megan L. Steele, “ Safety of Combined Treatment With Monoclonal Antibodies and Viscum album L Preparations ,” Integrative Cancer Therapies, pp. 153473541668164, 2016. View at Publisher · View at Google Scholar
  • Brahma N. Singh, Chaitrali Saha, Danijel Galun, Dalip K. Upreti, Jagadeesh Bayry, and Srini V. Kaveri, “European Viscum album: a potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence,” RSC Adv., vol. 6, no. 28, pp. 23837–23857, 2016. View at Publisher · View at Google Scholar
  • Gunver S. Kienle, Milena Mussler, Dieter Fuchs, and Helmut Kiene, “Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Exploring the Procedures, Concepts, and Observations of Expert Doctors,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–16, 2016. View at Publisher · View at Google Scholar
  • Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger, and Wilfried Tröger, “Safety of intravenously applied mistletoe extract – results from a phase I dose escalation study in patients with advanced cancer,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Leoni Villano Bonamin, Aloisio Cunha De Carvalho, and Silvia Waisse, “Viscum album (L.) in experimental animal tumors: A meta-analysis,” Experimental and Therapeutic Medicine, vol. 13, no. 6, pp. 2723–2740, 2017. View at Publisher · View at Google Scholar
  • Anja Thronicke, Megan L. Steele, Burkhard Matthes, Christian Grah, and Friedemann Schad, “Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Paul G. Werthmann, Alexander Hintze, and Gunver S. Kienle, “Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract,” Medicine, vol. 96, no. 46, pp. e8731, 2017. View at Publisher · View at Google Scholar
  • Anja Thronicke, Shiao Oei, Antje Merkle, Harald Matthes, and Friedemann Schad, “Clinical Safety of Combined Targeted and Viscum album L. Therapy in Oncological Patients,” Medicines, vol. 5, no. 3, pp. 100, 2018. View at Publisher · View at Google Scholar
  • Friedemann Schad, Anja Thronicke, Megan L. Steele, Antje Merkle, Burkhard Matthes, Christian Grah, and Harald Matthes, “Overall survival of stage IV non-small cell lung cancer patients treated with Viscum album L. in addition to chemotherapy, a real-world observational multicenter analysis,” Plos One, vol. 13, no. 8, pp. e0203058, 2018. View at Publisher · View at Google Scholar
  • Shiao Li Oei, Anja Thronicke, and Friedemann Schad, “Mistletoe and Immunomodulation: Insights and Implications for Anticancer Therapies,” Evidence-Based Complementary and Alternative Medicine, vol. 2019, pp. 1–6, 2019. View at Publisher · View at Google Scholar
  • Shiao Li Oei, Anja Thronicke, Matthias Kröz, Harald Matthes, and Friedemann Schad, “ Use and Safety of Viscum album L Applications in Cancer Patients With Preexisting Autoimmune Diseases: Findings From the Network Oncology Study ,” Integrative Cancer Therapies, vol. 18, pp. 153473541983236, 2019. View at Publisher · View at Google Scholar
  • Sophie Mavrikou, Vasileios Tsekouras, Maria-Argyro Karageorgou, Georgia Moschopoulou, and Spyridon Kintzios, “Anticancer and biochemical effects of Viscum album L. protein extracts on HeLa cells,” Plant Cell, Tissue and Organ Culture (PCTOC), 2019. View at Publisher · View at Google Scholar
  • Eric Yarnell, and Claire Zimmerman, “Herbal Medicines as Adjuncts to Cancer Chemotherapy—Part 1: Immunomodulators,” Alternative and Complementary Therapies, 2019. View at Publisher · View at Google Scholar
  • P. Werthmann, A. Hintze, and G.S. Kienle, “Vollständige Metastasenremission und Langzeitüberleben bei einer Melanompatientin unter hochdosierter, fieberinduzierender Viscum-album-Extrakt-Therapie,” Der Merkurstab, vol. 72, no. 1, pp. 36–42, 2019. View at Publisher · View at Google Scholar