Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation
Figure 1
PDM induced significant reduction of cell number, cell shrinkage, and apoptotic body formation in treated MCF-7 cells. (a) MCF-7 cells were treated with DMSO, doxorubicin, or different concentrations of PDM for 24 h. Live cell images indicating cell shrinkage and apoptosis in a dose-dependent manner. (b) MCF-7 cells were treated with DMSO or PDM (25 μg/mL) and were screened for 24 h using a real-time cellular analysis (JuLi Br) system. Real-time cell proliferation throughout the 24 hours of treatment indicating significant reduction of cell number, cell shrinkage, and formation of apoptotic body in the MCF-7 cells treated with PDM.
