ERK1/2-Egr-1 Signaling Pathway-Mediated Protective Effects of Electroacupuncture in a Mouse Model of Myocardial Ischemia-Reperfusion

Figure 5

Inhibiting ERK1/2 activation with U0126 protected the myocardium against I/R injury. After 24 h of reperfusion, Evans blue/TTC staining was applied to measure the infarct size ((a-b) 𝑛=6/group). AAR/LV: area at risk/left ventricle area; IA/AAR: infarct area/area at risk. After 3 h of reperfusion, the serum cTnI level (c, 𝑛=6/group) and the myocardial levels of TNF-α and IL-1β ((d-e) 𝑛=3/group) were determined using ELISA. ^∗𝑃<0.05 versus DMSO + IR.

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