Antimutagenicity of Methanolic Extracts from Anemopsis californica in Relation to Their Antioxidant Activity

Table 1

Mutagenic activity of SME and LME.

Strain

SR

DMSO

DMSO + S9

SME (𝜇g/Petri dish)

LME (𝜇g/Petri dish)

1000

500

250

1000

500

250

Without S9

With S9

Without S9

With S9

Without S9

With S9

Without S9

With S9

Without S9

With S9

Without S9

With S9

TA98

22.0±07.14

27±01.41

29±05.57

31±04.16

37±08.90

30±08.84

30±08.81

24±06.50

24±06.50

22±03.60

𝟒𝟒±11.99

28±02.80

28±04.79

19±02.00

30±08.84

TA100

132.0±16.66

155±26.41

146±17.67

148±25.78

182±16.30

—

—

—

—

177±39.68

185±26.24

—

—

—

—

TA102

305.0±50.91

345±67.22

322±40.60

315±60.78

356±35.86

—

—

—

—

373±55.50

396±44.16

—

—

—

—

SME and LME: stem and leaf methanolic extracts, respectively. SR: spontaneous revertants. Positive controls: TA98: picrolonic acid (PA) (50 𝜇g/Petri dish) without S9, 475.0±33.42, His⁺ revertants; (2AA) 2-aminoanthracene (10 𝜇g/Petri dish) with S9, 2354.83±222.49; TA100: methyl-N′-nitro-N-nitrosoguanidine (MNNG), (10 𝜇g/Petri dish) without S9, 5,881.17 ± 861.49, (CF) cyclophosphamide (500 𝜇g/Petri dish) with S9, 530.0±60.97; TA102: mitomycin C (2 ng/Petri dish) without, 3,401.67 ± 703.37, 2AA (10 𝜇g/Petri dish) 1,264.83 ± 77.38. S9 rat liver homogenate induced with aroclor 1254.