Review Article

Shenfu Injection for Intradialytic Hypotension: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.

Studies Methods Participants Cause of Renal Failure Intervention Outcomes Follow-up

(T/C)
AgeM/FTC

Chen 2011 [32]D: RCT
R: NM
A: NM
B: NM
36
(18/18, 216/216*)
()
()
11/17NM00:00
SFI 20 mL + 0.9% NS 130 mL
00:00
0.9% NS 150 mL
HI, BP, Dry weight4 w

Liang et al., 2011 [33]D: RCT
R: Random-number table
A: N
B: N
46
(23/23, 240/240*)
()
()
31/1521 CGN
13 DN, 7 ON, 3 HN,
2 GN
SOS: SFI 40 mL + CTSOS: CTBP, HR, ALB, CRP, Clinical effect3-4 w

Li 2012 [34]D: RCT
R: Random-
number table
A: N
B: N
34
(18/16, 468/416*)
()
()
23/11NMSOS: SFI 40 mL + CTSOS: CT HI, SBP, DBP, ALB, CRP.12 w

Ma and Fu 2011 [35]D: RCT
R: NM
A: NM
B: NM
40
(20/20, 720/696*)
29–72 (56.6)
30–74 (56.8)
27/1320 CGN
6 DN, 3 ON, 9 HN, 2 O
00:00
SFI 40 mL
SOS: CT
SOS: CT HI, Clinical symptom12 w

Ouyang 2009 [36]D: RCT
R: NM
A: NM
B: NM
30
(15/15, 150/150*)
()
()
13/17NM02:00
SFI 50 mL + 0.9% NS 250 mL
02:00
0.9% NS 300 mL
BP, CS, Intervention for IDH3–5 w

Zeng and Xian 2007 [37]D: RCT
R: Computer Software
A: N
Bi: N
60
(40/20, 1440/720*)
()
()
33/2728 CGN
11 DN, 12 ON, 3 HN,
6 O
SOS: SFI 20 mL + 50 g/L GS 30 mLSOS: 50 g/L GS 30 mL BP, HR, ALB, SE, HI, CRP, Serum osmolality12 w

Zhao 2012 [38]D: RCT
R: Random-
number table
A: N
B: N
52
(29/23)
()
()
33/1927 CGN
9 DN, 3 ON, 7 HN, 6 O
00:00
SFI 50 mL + 0.9% NS 50 mL
00:00
0.9% NS 100 mL
BP, ALB, SCR, HI, BUN, HB, ultrafiltration volume12 w

Zhong et al., 2013 [39]D: RCT
R: Random-
number table
A: N
B: N
55
(25/25, 250/250*)
()
()
23/277 CGN, 24 DN, 14 HN, 1 GN, 6 O00:10 & 02:00: SFI 20 mL + 50% GS 20 mL00:10 & 02:00
0.9% NS 40 mL
CS, Side effect.3–5 w

Notes: D: design; R: randomization; A: allocation concealment; B: binding; T/C: treatment group/control group; M/F: male/female; CGN: chronic glomerulonephritis; DN: diabetic nephropathy; ON: obstructive nephropathy; HN: hypertension nephropathy; O: others. HR: heart rate; HI: hypotension incidence; CS: clinical symptom; *hemodialysis sessions.
SOS: when hypotension happened during dialysis. 00:00, 00:10, 02:00: the time recorded as dialysis started.