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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 281829, 15 pages
Research Article

Study on Qi Deficiency Syndrome Identification Modes of Coronary Heart Disease Based on Metabolomic Biomarkers

1The Key Institute of State Administration of Traditional Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China
2Beijing University of Chinese Medicine, Beijing 100029, China

Received 15 December 2013; Accepted 11 February 2014; Published 27 March 2014

Academic Editor: Shao Li

Copyright © 2014 Qi Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Coronary heart disease (CHD) is one of the most important types of heart disease because of its high incidence and mortality. With the era of systems biology bursting into reality, the analysis of the whole biological systems whether they are cells, tissues, organs, or the whole organisms has now become the norm of biological researches. Metabolomics is the branch of science concerned with the quantitative understandings of the metabolite complement of integrated living systems and their dynamic responses to the changes of both endogenous and exogenous factors. The aim of this study is to discuss the characteristics of plasma metabolites in CHD patients and CHD Qi deficiency syndrome patients and explore the composition and concentration changes of the plasma metabolomic biomarkers. The results show that 25 characteristic metabolites related to the CHD patients comparing with the healthy people, and 4 identifiable variables had significant differences between Qi deficiency and non-Qi deficiency patients. On the basis of identifying the different plasma endogenous metabolites between CHD patients and healthy people, we further prompted the metabolic rules, pathogenesis, and biological essence in Qi deficiency syndrome patients.