Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 281829, 15 pages
http://dx.doi.org/10.1155/2014/281829
Research Article

Study on Qi Deficiency Syndrome Identification Modes of Coronary Heart Disease Based on Metabolomic Biomarkers

1The Key Institute of State Administration of Traditional Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China
2Beijing University of Chinese Medicine, Beijing 100029, China

Received 15 December 2013; Accepted 11 February 2014; Published 27 March 2014

Academic Editor: Shao Li

Copyright © 2014 Qi Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-H. Shi, H.-H. Zhao, N. Hou et al., “Identifying metabolite and protein biomarkers in Unstable angina in-patients by feature selection based data mining method,” Chemical Research in Chinese Universities, vol. 27, no. 1, pp. 87–93, 2011. View at Google Scholar · View at Scopus
  2. H. Zhao, S. Guo, J. Chen et al., “Characteristic pattern study of coronary heart disease with blood stasis syndrome based on decision tree,” in Proceedings of the 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE '10), June 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. Q. Shi, H. Zhao, J. Chen, Y. Yang, C. Zheng, and W. Wang, “Recognition patterns construction of coronary heart disease patients with qi deficiency syndrome based on Artificial Neural Network,” Advanced Materials Research, vol. 393-395, pp. 916–920, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. H. H. Zhao, J. X. Chen, Q. Shi, and W. Wang, “Gel electrophoresis analysis on plasma differential protein in patients with unstable angina of blood-stasis pattern,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 30, pp. 488–492, 2010. View at Google Scholar
  5. H. H. Zhao, S. Z. Guo, and N. Hou, “Study on proteome of angina blood stasis syndrome by 2D-difference gel electrophoresis and mass spectrometry,” China Journal Of Traditional Chinese Medicine And Pharmacy, vol. 23, pp. 1050–1063, 2008. View at Google Scholar
  6. M. D. Zhu, W. X. Du, M. Jiang et al., “Research ideas discussion between TCM syndromes and genes, proteins and metabolomics,” Chinese Journal of Basic Medicine in TCM, vol. 16, pp. 69–71, 2010. View at Google Scholar
  7. R. Li, T. Ma, J. Gu et al., “Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients,” Scientific Reports, vol. 3, pp. 1543–1543, 2013. View at Google Scholar
  8. S. Li, Z. Q. Zhang, L. J. Wu, X. G. Zhang, Y. D. Li, and Y. Y. Wang, “Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network,” IET Systems Biology, vol. 1, no. 1, pp. 51–60, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Zhang and Y. Li, “Thinking of the research paths about the TCM material basis,” Chinese Journal of Basic Medicine in Traditional Chinese Medicine, vol. 13, pp. 394–395, 2007. View at Google Scholar
  10. B. Jiang, X. J. Liang, Y. Chen et al., “Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome,” Scientific Reports, vol. 2, pp. 936–1019, 2012. View at Google Scholar
  11. H. H. Zhao, J. X. Chen, Q. Shi et al., “Metabolomics based study of clinical and animal plasma samples in Coronary Heart Disease with blood stasis syndrome,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 638723, 6 pages, 2012. View at Publisher · View at Google Scholar
  12. Y. Wang, Z. F. Li, J. X. Chen et al., “Study of mini-pig serum of coronary heart disease (chronic myocardial ischemia) with syndrome of blood stasis based on nuclear magnetic resonance metabolomic,” Chinese Journal of Analytical Chemistry, vol. 39, pp. 1274–1278, 2011. View at Google Scholar
  13. Y. Wang, C. Li, S.-Z. Guo et al., “Serum metabolomics of blood-stasis syndrome of chronic myocardial ischemia based on CPMG pulse sequence,” Journal of Beijing University of Traditional Chinese Medicine, vol. 34, pp. 819–822, 2011. View at Google Scholar
  14. R. J. Gibbons, K. Chatterjee, J. Daley et al., “ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina,” Journal of the American College of Cardiology, vol. 33, no. 7, pp. 2092–2190, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. Society of Cardiology, Chinese Medical Association, Editorial Committee of Chinese Journal of Cardiology, “Diagnosis and treatment recommendation of unstable angina cordis,” Chinese Journal of Cardiology, vol. 28, pp. 409–412, 2000. View at Google Scholar
  16. X. Y. Zheng, Guiding Principle of Clinical Research on New Drugs of Traditional Chinese Medicine (Trial), China Medic-Pharmaceutical Sciences and Technology, Beijing, China, 2002.
  17. W. F. Zhu and Y. Y. Wang, Terminology for Traditional Chinese Medicine Clinical Practice-Part of the Syndrome, China Standard, Beijing, China, 1997.
  18. J. H. Li, Z. J. Shao, Z. R. Wang, and J. Ma, “Feasibility and application of metabolomics to be used in research of nature of xiongbi syndromes,” Progress in Modern Biomedicine, vol. 9, pp. 4786–4788, 2009. View at Google Scholar
  19. M. Mayr, Y.-L. Chung, U. Mayr et al., “Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 10, pp. 2135–2142, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. J. T. Brindle, H. Antti, E. Holmes et al., “Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics,” Nature Medicine, vol. 8, no. 12, pp. 1439–1444, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. H. Hu, Y. Li, Q. Q. Song et al., “Serum metabolome in patients with CHD angina pectoris analysis,” in Proceedings of the China Association of Traditional Chinese Medicine-Heat Disease Symposium, vol. 2011, pp. 56–63.
  22. D. J. Deng, D. M. Li, Y. X. Jiang et al., “Changes of serum free amino acid in coronary heart disease,” Practical Geriatrics, vol. 5, pp. 114–115, 1991. View at Google Scholar
  23. L. P. Luo, A. P. Xu, F. Yin et al., “Clinical study on the detection of serum amino acid in acute cardiovascular disease patients,” Chinese Journal of Practical Internal Medicine, vol. 18, pp. 744–745, 1998. View at Google Scholar
  24. C. Bernal-Mizrachi, A. C. Gates, S. Weng et al., “Vascular respiratory uncoupling increases blood pressure and atherosclerosis,” Nature, vol. 435, no. 7041, pp. 502–506, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. K. Nicholson, J. Connelly, J. C. Lindon, and E. Holmes, “Metabonomics: a platform for studying drug toxicity and gene function,” Nature Reviews Drug Discovery, vol. 1, no. 2, pp. 153–161, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Song, C. W. Li, and W. X. Zhao, “Energy metabolism and metabolic drugs treatment in myocardial ischemia,” PJCCPVD, vol. 14, pp. 776–768, 2006. View at Google Scholar
  27. W. H. Liu, Q. Zhang, X. Z. Yan et al., “Metabonomics study on phlegm and blood stasis evolution of hyperlipidemia and atherosclerosis,” Journal of Traditional Chinese Medicine, vol. 49, pp. 738–741, 2008. View at Google Scholar
  28. H.-P. Cheng, S. Wei, L.-P. Wei, and A. Verkhratsky, “Calcium signaling in physiology and pathophysiology,” Acta Pharmacologica Sinica, vol. 27, no. 7, pp. 767–772, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. F. Lu and B. Q. Zhou, “The medicinal function of lysine,” Journal of Pharmaceutical Practice, vol. 14, pp. 255–256, 1996. View at Google Scholar
  30. R. B. Luo, G. L. Zhang, and W. F. Liu, “Effects of lysine supplement on Bax and Bcl-2 of cardiac and hepatic tissue of rats,” Journal of Physical Education, vol. 15, pp. 94–98, 2008. View at Google Scholar
  31. Y. H. Liang and Y. L. Wang, “Clinical research and application of L-carnitine,” Medical Recapitulate, vol. 10, pp. 443–445, 2004. View at Google Scholar
  32. R. F. Yang, Z. Y. Li, and G. B. Xu, “Biological characteristics of carnitine and its relationship with clinical disease,” Chinese Journal of Laboratory Diagnosis, vol. 9, pp. 310–313, 2005. View at Google Scholar
  33. F. L. Wang and G. L. Liu, “Correlative research of plasma free carnitine lever in diabetes patients accompanied with coronary heart disease,” Chinese Journal of Misdiagnosis, vol. 6, pp. 3687–3688, 2006. View at Google Scholar
  34. Y. L. Xing and L. Z. Yu, “Progress in the mechanism of sleep deprivation and intervention of traditional Chinese Medicine,” Clinic and Pharmacology of Traditional Chinese Medicine, vol. 19, pp. 47–49, 2003. View at Google Scholar
  35. N. P. Walsh, A. K. Blannin, P. J. Robson, and M. Gleeson, “Glutamine, exercise and immune function: Links and possible mechanisms,” Sports Medicine, vol. 26, no. 3, pp. 177–191, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. F. S. Wan, Z. J. Zeng, X. M. Zhao et al., “Effects of Taurine on dysfunction of myocardial nuclear calcium transport in rat myocardial injury induced with isoproterenol,” Chinese Journal of Clinical Pharmacology and Therapeutics, vol. 5, pp. 25–27, 2000. View at Google Scholar
  37. C. B. Sun, P. Qu, and C. G. Yang, “The effect of taurine on the apoptosis of donor cardiocytes during the hypothermic preservation in rat,” Progress of Anatomical Sciences, vol. 14, pp. 402–405, 2008. View at Google Scholar