Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3/NF-B Signaling Pathway
Figure 1
Effect of APS on the growth and proliferation of astrocytes. (a) Blank control group: the astrocytes grew in good condition with active proliferation. (b) HSV-1 group: 12 h after infection with HSV-1, the proliferation of astrocytes was significantly inhibited and the infected astrocytes’ bodies were gradually swollen into round and giant appearance. (c) HSV-1 + APS group: the proliferation inhibitory effect of HSV-1 could be suppressed by APS, and most astrocytes grew in good conditiosn. (d) TLR3 antibody + HSV-1 + APS group: when astrocytes were pretreated with TLR3 antibody, the proliferation of astrocytes reduced markedly, and some infected astrocytes’ bodies were swollen into round appearance. Scale bar: 20 μm.
