Differential Effects of Naja naja atra Venom on Immune Activity

Figure 5

NNAV increased the CD4/CD8 T cell ratio in DEX-induced immunosuppressed mice. The DEX-induced immunosuppressed C57BL/6J mice were treated with NNAV for 21 days. Then splenocytes were prepared and stained with CD3e-PE-cy5, CD4-PE, and CD8a-FITC for analysis with flow cytometer. The percentage of CD3⁺CD4⁺T-cell (a) and CD3⁺CD8⁺T-cell (b) and the ratio of the two (c) are shown. Data represent mean values ± SD for 8 mice per group. ^∗𝑃<0.05 (versus model); ^#𝑃<0.05 (versus normal).

(a)

(b)

(c)