Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

Table 1

Effects of BBR on parameters of oxidative stress in animals with diabetes mellitus.

ReferencesDiabetic animal modelAdministration of BBR Tissues
examined
Effects of BBR
Oxidative stress markers Antioxidant enzymes
MDAGSHSODGSH-Px

[27]Wistar rats, STZ 60 mg/kg, single i.p. injection200 mg/kg/d, p.o. for 12 weeksSerum ND ND

[28]SD rats, STZ 60 mg/kg, single tail vein injection200 mg/kg/d, p.o. for 12 weeksSerum ND ND

[29]Wistar rats, STZ 35 mg/kg, single i.p. injection, HFD for 14 weeks after 2 weeks on diabetes75, 150, and 300 mg/kg/d, p.o. for 16 weeksSerum and liver

[30]ddY mice, STZ 100 mg/kg, single i.p. injection200 mg/kg/d, p.o. for 2 weeksLiverND

[31]SD rats, HFD for 2 weeks, then STZ 35 mg/kg, single i.p. injection50, 100, and 150 mg/kg/d, p.o. for 6 weeksLiverND

[32]ICR mice, nicotinamide 1000 mg/kg + STZ 100 mg/kg, single i.p. injection100 mg/kg/d, p.o. for 2 weeksLiver and kidney ND ND

[33]SD rats, HFD for 4 weeks, then STZ 40 mg/kg, single i.p. injection, HFD for another 8 weeks100 and 200 mg/kg/d, p.o. for 8 weeksKidney ND ND

[34]Wistar rats, STZ 35 mg/kg, single i.p. injection, HFD for 14 weeks after 2 weeks on diabetes75, 150 and 300 mg/kg/d, p.o. for 16 weeksPancreas ND ND

[35]Wistar rats, alloxan 55 mg/kg, single tail vein injection, then on HFD100 and 200 mg/kg/d, p.o. for 21 daysHeart ND

[36]Wistar rats, STZ 60 mg/kg, single i.p. injection25, 50, and 100 mg/kg/d, p.o. for 30 daysCortex and hippocampus NDND

[37]Wistar rats, STZ 55 mg/kg, single i.p. injection50 and 100 mg/kg/d, p.o. for 8 weeksHippocampus ND ND

: decrease, : increase, ND: not determined, —: no effect; BBR: berberine, MDA: malondialdehyde, GSH: glutathione, SOD: superoxide dismutase, GSH-Px: glutathione peroxidase, STZ: streptozotocin, p.o.: per os/oral administration, i.p.: intraperitoneal, HFD: high fat diet.

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