Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 2

Review Article

Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

Table 2

Effects of BBR on inflammatory cytokines and inflammation in cultured cells or animals with diabetes mellitus or insulin resistance.

ReferencesCell type, animal modelAdministration of BBRSamples examinedEffects of BBR

[42]3T3-L1 adipocytes10 μM for 18 hours3T3-L1 adipocytes : TNF- , IL-6, CRP, and HP mRNAs

[43]HepG2 cells, palmitate induced insulin resistance0.1–10 μM for 24 hoursCulture media : TNF- , IL-6

[44]RAW 264.7 macrophages treated with LPS5 μM pretreated for 2 hours before LPS treatment for 6 hoursRAW 264.7 macrophages : IL-1 , IL-6, MMP9, COX2, and iNOS mRNAs

[45]Mouse primary splenocytes treated with or without LPS0.8–3.3 μM for 48 hoursCulture media : TNF- , IL-6

[46]NIT-1 pancreatic -cells treated with LPS1.25–5 μM for 24 hoursCulture media : TNF- , IL-6, and MCP-1

[47]KM mice, obesity and insulin resistance induced by HFD feeding for 13 weeks50 or 150 mg/kg/d, p.o. for 2 weeksSerum : TNF- , IL-6

[48]Wistar rats, STZ 50 mg/kg, single i.p. injection100 mg/kg/d, p.o. for 7 weeksSerum : CRP

[49]Wistar rats, NAFLD and insulin resistance induced by HFD for 8 weeks187.5 mg/kg/d, p.o. for 4 weeksLiver : inflammatory cell infiltration

[44]db/db mice5 mg/kg/d, i.p. for 4 weeksWhite adipose tissue : TNF- , IL-1 , IL-6, MCP-1, iNOS, and COX2 mRNAs

[28]SD rats, STZ 60 mg/kg, single tail vein injection200 mg/kg/d, p.o. for 12 weeksKidney : ICAM-1, TGF- 1 protein expression

[50]NOD mice 200 mg/kg/d, p.o. for 2 weeksSupernatant from splenocytes, CD4+ T cells from spleen/lymph nodes : TNF- , IL-6, IFN and IL-17

[51] NOD mice 50, 150 and 500 mg/kg/d, p.o. for 14 weeksSupernatant from splenocytes : IL-10/IL-1 and IL-10/IL-6 ratios; : IFN
Kidney and liver : IL-10/IL-6 and IL-10/TNF- ratios of mRNA levels

: decrease, : increase; BBR: berberine, LPS: lipopolysaccharide, KM mice: Kunming mice, HFD: high fat diet, STZ: streptozotocin, NAFLD: nonalcoholic fatty liver disease, p.o.: per os/oral administration, i.p.: intraperitoneal, TNF- : tumor necrosis factor- , IL: interleukin, CRP: C-reaction protein, HP: haptoglobin, MMP9: matrix metalloprotease 9, COX2: cyclooxygenase-2, iNOS: inducible nitric oxide synthase, MCP-1: monocyte chemoattractant protein 1, ICAM-1: intercellular adhesionmolecule-1, TGF- 1: transforming growth factor- 1, IFN : interferon- .

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