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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 308126, 9 pages
Research Article

Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers

1The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 816 Zhenli Road, Hebei District, Tianjin 300150, China
2Tasly Research Institute, Tasly Pharmaceutical Group Co., Ltd., No. 2 Pujihe East Road, Beichen District, Tianjin 300041, China
3Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, China
4Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, China

Received 13 November 2013; Accepted 11 January 2014; Published 6 April 2014

Academic Editor: Syed Ibrahim Rizvi

Copyright © 2014 Huang Yuhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ethnopharmacological Relevance. TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes. Aim of the Study. This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose. Methods. The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect. Results. 3 and 4 tablets of TZQ decreased the of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased of plasma C-peptide compared with placebo. 4 tablets increased of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the of plasma insulin and C-peptide after breakfast and the of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events. Conclusions. 3 tablets of TZQ have the same effects as the acarbose.