A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC

Table 7

Reported IC₅₀ values (𝜇g/mL) of selected P. bleo phytoconstituents on human cell lines [28].

Compound	IC50 (𝜇g/mL) of different cell lines
	KB	MCF7	CasKi	HCT 116	A549	MRC-5
Dihydroactinidiolide	6.7	30	40	5	97	91.3
𝛽-sitosterol	>100	72	62	>100	78	>100
2,4-ditertbutylphenol	0.81	5.75	4.5	29	6	20
𝛼-tocopherol	8	7.5	6	31	6	30.5
Phytol	7.1	34	18	100	31	74.1
Mixture of sterols	>100	>100	>100	>100	>100	>100
Doxorubicin	1.3 × 10^−2	7.6 × 10^−2	6.0 × 10^−3	3.6 × 10^−1	2.2 × 10^−1	5.5 × 10^−1

A549: human lung carcinoma cell line, CasKi: human cervical carcinoma cell Line, HCT116: human colon carcinoma cell Line, KB: human nasopharyngeal epidermoid carcinoma cell Line, MCF-7: hormone dependent breast carcinoma cell Line, MRC-5: normal human fibroblast cell Lines.