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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 343176, 17 pages
http://dx.doi.org/10.1155/2014/343176
Review Article

Effectiveness, Medication Patterns, and Adverse Events of Traditional Chinese Herbal Patches for Osteoarthritis: A Systematic Review

1Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China
2Institute of Traumatology & Orthopedics, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China

Received 5 June 2013; Revised 17 August 2013; Accepted 18 August 2013; Published 14 January 2014

Academic Editor: Byung-Cheul Shin

Copyright © 2014 Xuezong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. T. Felson, “Osteoarthritis of the knee,” The New England Journal of Medicine, vol. 354, no. 8, pp. 841–848, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. E. M. Debbi, G. Agar, G. Fichman et al., “Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study,” BMC Complementary and Alternative Medicine, vol. 11, article 50, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. Chinese Medical Association of Orthopaedics, “Osteoarthritis guidelines of diagnosis and treatment,” Chinese Journal of Joint Surgery, vol. 1, no. 4, pp. 281–283, 2007. View at Google Scholar
  4. X. Wang, Y. Cao, J. Pang et al., “Traditional Chinese herbal patch for short-term management of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 171706, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Long, K. Soeken, and E. Ernst, “Herbal medicines for the treatment of osteoarthritis: a systematic review,” Rheumatology, vol. 40, no. 7, pp. 779–793, 2001. View at Google Scholar · View at Scopus
  6. E. Ernst, “Herbal medicine in the treatment of rheumatic diseases,” Rheumatic Disease Clinics of North America, vol. 37, no. 1, pp. 95–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Ernst and P. Posadzki, “Complementary and alternative medicine for rheumatoid arthritis and osteoarthritis: an overview of systematic reviews,” Current Pain and Headache Reports, vol. 15, no. 6, pp. 431–437, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. P. Xu, L. M. Xie, and W. Y. Wang, “Meta-analysis on external use of tradition Chinese medicine (TCM) in treating knee osteoarthritis,” China Journal of Chinese Materia Medica, vol. 37, no. 19, pp. 2977–2984, 2012. View at Google Scholar
  9. M. C. Hochberg, R. D. Altman, K. April et al., “American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip and knee,” Arthritis Care and Research, vol. 64, no. 4, pp. 465–474, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Cao, H. Zhan, J. Pang et al., “Individually integrated traditional Chinese medicine approach in the management of knee osteoarthritis: study protocol for a randomized controlled trial,” Trials, vol. 12, no. 1, article 160, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. W. H. Hsu, T. J. Ho, C. Y. Huang et al., “Chinese medicine acupoint herbal patching for allergic rhinitis: a randomized controlled clinical trial,” American Journal of Chinese Medicine, vol. 38, no. 4, pp. 661–673, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. J. Kuang, “Zhong Tong Xiao Papua patch for the treatment of osteoarthritis of the knee 48 cases,” Hunan Journal of Chinese Medicine, vol. 24, no. 3, pp. 62–63, 2010. View at Google Scholar
  13. X. H. Du, “Clinical observation of Gu Bi Xi Tong Papua patch for the topical treatment of knee osteoarthritis,” Journal of New Chinese Medicine, vol. 42, no. 9, article 55, 2010. View at Google Scholar
  14. C. Hu, R. M. Chen, S. M. Yin et al., “Observation on analgesic effect and mechanism of Fufang Nanxing Zhitong Gao,” Journal of Nanjing Niversity of Traditional Chinese Medicine, vol. 25, no. 2, pp. 140–142, 2009. View at Google Scholar
  15. H. M. Bian, J. H. Yu, M. Jiang, and L. Sun, “Anti-inflammatory effect of Fufang Nanxing Zhitong Gao,” Pharmacology and Clinics of Chinese Materia Medica, vol. 23, no. 5, pp. 164–165, 2007. View at Google Scholar
  16. R. S. Hinman, K. M. Crossley, J. McConnell, and K. L. Bennell, “Efficacy of knee tape in the management of osteoarthritis of the knee: blinded randomised controlled trial,” British Medical Journal, vol. 327, no. 7497, p. 135, 2003. View at Google Scholar · View at Scopus
  17. China State Administration of Traditional Chinese Medicine, Clinical Path of Traditional Chinese Medicine 22 Professional 95 Diseases, China Traditional Chinese Medicine Press, Beijing, China, 2011.
  18. X. M. Gao, Traditional Chinese Medicine, China Press of Traditional Chinese Medicine, Beijing, China, 2002.
  19. S. Xutian, D. Cao, J. Wozniak, J. Junion, and J. Boisvert, “Comprehension of the unique characteristics of traditional Chinese medicine,” American Journal of Chinese Medicine, vol. 40, no. 2, article 231, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. J. G. Zhang, D. M. Fu, and C. L. Yang, “The clinical research about the therapy of bone arthritis of knee joint by Zhitong Tougu Ointment,” China Medical Herald, vol. 8, no. 5, pp. 45–46, 2008. View at Google Scholar
  21. P. Wang, E. P. Gu, and H. Y. Cao, “Clinical observation of Huo Xue Hua Yu patch for the treatment of early and mid-osteoarthritis of the knee,” Jilin Traditional Chinese Medicine, vol. 30, no. 6, pp. 491–493, 2010. View at Google Scholar
  22. Z. Y. Guan, “Zhuanggu Tongbi cream in treatment of knee osteoarthritis clinical research,” Clinical Journal of Chinese Medicine, vol. 2, no. 7, p. 14, 15, 17, 2010. View at Google Scholar
  23. Y. X. Zheng, H. S. Zhan, H. Zhang, S. G. Niu, and Z. J. Zhuang, “Qi-zheng Qing-peng slurry for treatment of the knee osteoarthritis: a randomized, controlled clinical research,” China Journal of Orthopaedics and Traumatology, vol. 19, no. 5, pp. 316–317, 2006. View at Google Scholar
  24. X. L. Sun, “Huangbo Wuwei patch for the treatment of knee osteoarthritis 90 cases,” Modern Traditional Chinese Medicine, vol. 29, no. 5, pp. 46–47, 2009. View at Google Scholar
  25. L. Lin, “Clinical observation of Shang Ke Xiao Yan patch for the topical treatment of the cold-damp stasis of knee osteoarthritis,” Morden Medicine Drug and Health, vol. 22, no. 18, pp. 2786–2787, 2006. View at Google Scholar
  26. C. Q. Long, “Clinical observation of Guan Jie Yan patch for the topical treatment of knee osteoarthritis,” Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 15, no. 18, article 2494, 2006. View at Google Scholar
  27. J. Liao, F. M. Lv, and Q. C. Meng, “Clinical efficacy of Re Yun I recipe to treat type of Yang Xu Han Nin in knee osteoarthritis,” Xinjiang Medical University, vol. 33, no. 8, p. 988, 989, 992, 2010. View at Google Scholar
  28. J. P. Liu, M. H. Yang, Y. Qiu, and T. J. Huang, “Observed clinical efficacy of traditional Chinese medicine for the topical treatment of osteoarthritis of the knee,” Xinjiang Traditional Chinese Medicine, vol. 22, no. 1, pp. 15–16, 2004. View at Google Scholar
  29. J. Shen, J. Y. Chen, X. L. Yun, Q. Q. Zhu, and Y. X. Li, “Clinical comparative study on self-made Tongluo Qing Bi patch for the treatment of knee osteoarthritis,” Journal of Guiyang College of Traditional Chinese Medicine, vol. 33, no. 2, pp. 37–38, 2011. View at Google Scholar
  30. Y. Q. Yang, “Clinical study of Gu Zeng Sheng Zheng Tong for the treatment of osteoarthritis,” Traditional Chinese Drug Research & Clinical Pharmacology, vol. 10, no. 3, pp. 138–140, 1999. View at Google Scholar
  31. Z. Q. Long, “Clinical observation of Guan Jie Yan patch for the topical treatment of knee osteoarthritis,” Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 15, no. 18, p. 2494, 2006. View at Google Scholar
  32. M. C. Pan, “Gu Tong Ning patch for the treatment of knee osteoarthritis 216 cases,” China Foreign Medical Ttreatment, vol. 27, no. 24, pp. 15–16, 2008. View at Google Scholar
  33. Y. Zhang and Y. M. Xin, “Clinical observation of homemade Wentong patch for the topical treatment of osteoarthritis of the knee,” Chinese Manipulation & Rehabilitation Medicine, vol. 1, no. 16, pp. 52–53, 2010. View at Google Scholar
  34. H. Wen, W. H. Zhao, and X. C. Li, “Clinical observation of Xi Tong Gao for the treatment of osteoarthritis of the knee,” Jilin Journal of Traditional Chinese Medicine, no. 9, article 664, 2008. View at Google Scholar
  35. Q. Zhang, J. Xiao, and L. Dun, “Clinical study of Shexiang Tongbi Pupua patch for the treatment of the symdrone of liver and kedney defficious and stens-muslcuar stasis of oateoarthritis,” Chinese Journal of Clinical Pharmacology and Therapeutics, vol. 18, no. 8, pp. 953–956, 2005. View at Google Scholar
  36. J. F. Guo, Z. Q. Du, T. Z. Bao et al., “Clinical study of Xiong Zhi Tong Yu Xiao San Tie on knee pain (blood stasis syndrome) induced by osteoarthritis,” World Journal of Integrated Traditional and Western Medicine, vol. 26, no. 8, pp. 468–470, 2008. View at Google Scholar
  37. G. S. Ding, Q. R. Shen, and H. Y. Xie, “Preparation and clinical observation of Kang Wei Tong Bi patch,” Chinese Anchive of Traditional Chinese Medicine, vol. 26, no. 3, pp. 582–583, 2008. View at Google Scholar
  38. Z. A. Tan and J. W. Li, “Clinical study of Jinghuang for knee plaster on external application for knee osteoarthritis,” Journal of Traditional Chinese Medicine University of Hunan, vol. 30, no. 7, p. 73, 2010. View at Google Scholar
  39. E. P. Xu, G. L. Li, Q. H. Yang, and S. Q. Jang, “Gu Bi patch for the treatment of knee osteoarthritis 78 cases,” New Traditional Chinese Medicine, vol. 34, no. 10, p. 56, 2002. View at Google Scholar
  40. S. C. Bai, Z. G. Wang, F. J. Zhang, H. Li, and L. H. Zeng, “Clinical research of Gu Tong patch in curing proliferative arthritis of knee joint,” Chinese Journal of Traditional Medicine Traumatology & Orthopedics, no. 8, pp. 474–475, 2004. View at Google Scholar
  41. J. X. Wu, C. X. Huang, J. Y. Lin, and Z. L. Tang, “Clinical observation of Xi Tong Ning patch for the topical treatment of knee osteoarthritis,” China Journal of Orthopaedics and Traumatology, vol. 18, no. 5, article 314, 2005. View at Google Scholar
  42. J. P. Liu, M. H. Yang, Y. Qiu, and T. J. Huang, “Observed clinical efficacy of traditional Chinese medicine for the topical treatment of osteoarthritis of the knee,” Xinjiang Traditional Chinese Medicine, vol. 22, no. 1, pp. 15–16, 2004. View at Google Scholar
  43. K. H. Feng, “Clinical efficacy judgment of Gu Ci patch for the treatment of osteoarthritis of the knee,” Health Vocational Education, vol. 09, pp. 141–142, 2006. View at Google Scholar
  44. Y. F. Cheng, S. F. Gu, and M. Liu, “San Huang patch for the topical treatment of knee osteoarthritis 63 cases,” Shenzhen Journal of Integrated Traditional and Western Medicine, vol. 19, no. 3, p. 190, 200, 2009. View at Google Scholar
  45. J. M. Wang and L. W. Wu, “Zheng Tong Xiao Yan patch for the treatment of osteoarthritis 66 cases,” Heilongjiang Journal of Traditional Chinese Medicine, no. 6, pp. 13–14, 2005. View at Google Scholar
  46. Z. Dong, “Clinical research of Shujin patch for the treatment of osteoarthritis of the knee,” Journal of Fujian College of Traditional Chinese Medicine, vol. 17, no. 3, pp. 46–47, 2007. View at Google Scholar
  47. A. L. Zhao, “Report of 112 cases about Gu Bi Tong patch for the topical treatment of bone and joint disease,” Zhejiang University of Traditional Chinese Medicine, vol. 177, no. 1, pp. 94–95, 2007. View at Google Scholar
  48. B, Xu, and J. F. Lu, “Clinical research of Fu Fang San Sheng patch for the treatment of knee ostoarthritis,” Clinical Medicine, vol. 20, no. 9, pp. 13–14, 2000. View at Google Scholar
  49. S. G. Liu and Y. G. Jiang, “Hei Hu patch for the treatment of knee osteoarthritis 260 cases,” Shanxi Journal of Traditional Chinese Medicine, vol. 319, no. 7, pp. 820–821, 2008. View at Google Scholar
  50. L. Zhang, L. Dong, D. Z. Zhao, and D. J. Zhang, “Observation on treating osteoarthritis pain with Gu Ci Xiao cataplasm,” Chinese Journal of the Practical Chinese With Modern Medicine, vol. 23, no. 7, pp. 12–13, 2010. View at Google Scholar
  51. J. L. Yan, F. R. Cheng, X. J. Wang, J. Y. Tang, B. G. Wu, and Y. X. Ling, “Clinical observation of Le E acupoint patch for the treatment of knee osteoarthritis 50 cases,” Chinese Journal of Traditional Medical Science and Technology, no. 6, pp. 407–409, 2000. View at Google Scholar
  52. X. H. Zhou, D. Lin, W. C. Meng, F. Li, and H. S. Lin, “Clinical study of Gu Ci Ning patch for the treatment of deenerative joint disease 100 cases,” Guangzhou University of Traditional Chinese Medicine, vol. 17, no. 1, pp. 30–34, 2000. View at Google Scholar
  53. X. L. Du and H. Zhang, “Clinical research of Ji Li Huo Xue patch for the treatment of knee osteoarthritis,” Journal of Shandong University of Traditional Chinese Medicine, vol. 21, no. 6, pp. 443–445, 1997. View at Google Scholar
  54. B. Shi and G. Li, “Clinical study on Fu Fang Huo Xue patch for the topical treatment of osteoarthritis of the knee (0–II period),” Journal of External Therapy of Traditional Chinese Medicine, no. 5, pp. 3–5, 2006. View at Google Scholar
  55. H. Yin, Y. Ma, and J. W. Wang, “Patching therapy for the treatment of knee osteoarthritis 60 cases,” Traditional Chinese Medicine, vol. 26, no. 5, pp. 17–18, 2011. View at Google Scholar
  56. Y. Q. Chen, J. H. Wu, H. M. Yao, J. Y. Lv, Y. L. Sun, and S. M. Yin, “Clinical study on compound nanxing pain paste in treating 249 cases of osteoarthritis of cold dampness and blood stasis,” Shanghai Journal of Traditional Chinese Medicine, vol. 44, no. 12, pp. 59–61, 2010. View at Google Scholar
  57. Y. G. Wang, D. Y. Wei, F. C. Wang, and X. L. Liang, “Feng Shi Gu Tong patch for the treatment of osteoarthritis,” China's Naturopathy, vol. 16, no. 2, p. 16, 2008. View at Google Scholar
  58. Y. Y. Wang and H. J. Liu, “Clinical observation of Xiao Tong patch for knee osteoarthritis 41 cases,” Chongqing Medicine, vol. 35, no. 18, pp. 1696–1997, 2006. View at Google Scholar
  59. S. J. Shao, L. X. Ji, N. Liu, S. M. Liu, and Q. Tu, “Syndrome differentiation of limbs and meridians,” in Internal Medicine of Traditional Chinese Medicine, X. M. Shi, X. M. Dai, and J. Wang, Eds., pp. 409–415, China Traditional Chinese Medicine Press, Beijing, China, 2009. View at Google Scholar
  60. H. Q. Wang, Y. Y. Wang, W. X. Li, Y. C. Zou, and B. Liu, “Clinical efficacy of compound Nanxing Zhitong Ointment on agonizing-arthragia type knee osteoarthritis,” Journal of New Chinese Medicine, vol. 44, no. 8, pp. 88–90, 2012. View at Google Scholar
  61. J. X. Wu, C. X. Huang, J. Y. Lin, and Z. L. Tang, “Clinical observation of Xi Tong Ning patch for the topical treatment of knee osteoarthritis,” China Journal of Orthopaedics and Traumatology, vol. 18, no. 5, article 314, 2005. View at Google Scholar
  62. X. S. Zhou, D. B. Yi, J. Y. Zhu, and K. Zhou, “Preparation and clinical appliance of Wei Ling Xian patch,” Chinese Journal of Hospital Pharmacy, vol. 8, pp. 84–85, 2006. View at Google Scholar
  63. H. J. Wang and X. Z. Fan, “Clinical observation Gu Zhi Zhi Tong patch for the treatment of bi-arthralgia of cervical spondylos,” Practical Traditional Chinese Medicine, vol. 11, no. 12, article 1127, 1998. View at Google Scholar
  64. F. T. Hao, Z. G. Jiang, C. Y. Tian et al., “Effeciacy observation of Fufang Lingzhi patch for the treatment of osteoarthritis of the knee,” Research of Traditional Chinese Medicine, vol. 15, no. 6, pp. 17–19, 1999. View at Google Scholar
  65. Y. L. Yin, X. Q. Wang, and Q. H. Li, “Ru Gui patch for the topical treatment of knee osteoarthritis 100 cases,” Journal of Henan College of Traditional Chinese Medicine, no. 3, article 38, 1999. View at Google Scholar
  66. H. M. Li, F. L. Liu, and S. Q. Guo, “Yao Tong Ning patch for the topical treatment of osteoarthritis of the knee 48 cases,” Journal of External Therapy of Traditional Chinese Medicine, vol. 18, no. 6, article 28, 2009. View at Google Scholar
  67. M. P. Li, Q. B. Han, Q. Q. Wang, Y. F. Zhang, and Q. S. Ma, “Homemade Mei Po Zheng Gu patch for the treatment of bone hyperplasia 132 cases,” Clinical Medicine of Traditional Chinese Medicine, vol. 17, no. 2, article 181, 2005. View at Google Scholar
  68. X. P. Ren, “Gu Ci Ting patch for the treatment of bone hyperplasia in 528 patients,” Shanxi Journal of Traditional Chinese Medicine, vol. 14, no. 4, article 41, 1998. View at Google Scholar
  69. H. J. Tao, “Young's Xiao Zhong Zhi Tong patch for the treatment of bone hyperplasia of lumbar spine 200 cases,” Jangsu Journal of Traditional Chinese Medicine, vol. 26, no. 3, article 39, 2005. View at Google Scholar
  70. F. T. Hao, Q. L. Hao, Z. G. Jiang, G. W. Xiu, C. S. Yan, and T. Yan, “Effeciacy observation of Feng Shi Shang Tong patch for the treatment of osteoarthritis of the knee,” Journal of External Therapy of Traditional Chinese Medicine, vol. 8, no. 6, pp. 43–44, 1999. View at Google Scholar
  71. M. Li, P. F. Xiu, and C. G. Zhu, “Ba Wei patch for the treatment of knee osteoarthritis 80 cases,” Shanxi Journal of Traditional Chinese Medicine, vol. 30, no. 4, pp. 433–434, 2009. View at Google Scholar
  72. G. Liu, “Efficacy observation of Qizheng Xiaotong patch for the treatment of osteoarthritis of the knee,” Contemporary Medicine, vol. 17, no. 21, pp. 160–161, 2011. View at Google Scholar
  73. L. C. Su, “Clinical observation of Jiegu patch for the treatment of osteoarthritis of the knee effusion,” Chinese Medicine Morden Distance Education of China, vol. 8, no. 17, pp. 246–247, 2010. View at Google Scholar
  74. C. H. Zeng, X. H. Su, and J. L. Zhao, “Tong Yu patch for the treatment of osteoarthritis of the knee 25 cases,” Hunan Journal of Traditional Chinese Medicine, vol. 26, no. 4, pp. 51–53, 2010. View at Google Scholar
  75. G. D. Liu, Systematic review of oral tradition Chinese medicine (TCM) in treating knee osteoarthritis [M.S. thesis], Heilongjiang University of Traditional Chinese Medicine, Heilongjiang, China, 2010.
  76. D. Moher, S. Hopewell, K. F. Schulz et al., “CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials,” Journal of Clinical Epidemiology, vol. 63, no. 8, pp. e1–e37, 2010. View at Publisher · View at Google Scholar · View at Scopus
  77. Z. J. Deng, “Damp-draining formulae,” in Traditional Chinese Medical Formulae, p. 263, China Traditional Chinese Medicine Press, Beijing, China, 2003. View at Google Scholar
  78. J. Q. Pan, L. Y. Xiao, D. Zhang et al., “Immunosuppressive, antioxidant, anti-inflammatory and analgesic effect of Xiao Huo Luo Dan(pill),” Guangdong Pharmaceutical, vol. 13, no. 3, pp. 28–32, 2003. View at Google Scholar
  79. D. Wei, “Xiao Huo Luo Dan(pill) for the treatment of early and mid-knee osteoarthritis 120 cases,” The Journal of Traditional Chinese Orthopaedics and Traumatology, vol. 22, no. 7, p. 50, 52, 2010. View at Google Scholar
  80. Z. J. Deng, “Wind-expelling formulae,” in Traditional Chinese Medical Formulae, pp. 316–317, China Traditional Chinese Medicine Press, Beijing, China, 2003. View at Google Scholar
  81. S. Teekachunhatean, P. Kunanusorn, N. Rojanasthien et al., “Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892],” BMC Complementary and Alternative Medicine, vol. 4, article 19, 2004. View at Publisher · View at Google Scholar · View at Scopus
  82. Z. R. Li and C. Q. Lv, “Du Huo Ji Sheng Tang (decoction) for the treatment of knee osteoarthritis 36 cases by oral administration and external washing,” Shanxi Journal of Traditional Chinese Medicine, vol. 32, no. 9, pp. 1168–1169, 2011. View at Google Scholar
  83. W. L. Wang, J. X. Ye, X. X. Liu, F. E. Shen, P. Li, and Y. Y. Zhang, “Clinical observation of Du Huo Ji Sheng Tang(decoction) for the treatment of knee osteoarthritis 66 cases by oral administration and external washing,” Journal of Fujian University of Traditional Chinese Medicine, vol. 21, no. 2, pp. 44–45, 2011. View at Google Scholar
  84. Y. Cao, J. P. Yao, J. N. Dong, Y. H. Lin, and J. Z. Gao, “Clinical observation of Qu Tong patch for the treatment of degenerative knee joint disease,” Liaoning Journal of Traditional Chinese Medicine, vol. 29, no. 8, pp. 474–475, 2002. View at Google Scholar
  85. C. Wang, “Clinical research of Fu Fang Yan Ning patch for the treatment of bone hyperplasia,” Chinese Journal Traditional Medicine Traumatology & Orthopedics, no. 8, pp. 46–48, 2002. View at Google Scholar
  86. Y. Zhang, Y. L. Xie, Q. T. Zhang, T. Ma, and L. J. Li, “Clinical observation of Qu Yu Zhi Tong patch for the treatment of osteoarthritis of the knee,” Inner Mongolia in Traditional Chinese Medicine, vol. 30, no. 14, pp. 29–30, 2011. View at Google Scholar
  87. X. S. Zhou and D. B. Yi, “Pharmacodynamical research on anti-inflammatory of Wei Ling Xian,” Chinese Journal of Clinical Medicine and Pharmacy, vol. 4, pp. 12–13, 2003. View at Google Scholar